Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons

Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons

This review provides insight into the role of engineered T-cell receptors (TCRs) in immunotherapy. Novel approaches have been developed to boost anticancer immune system, including targeting new antigens, manufacturing new engineered or modified TCRs, and creating a safety switch for endo-suicide ge...

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Bibliographic Details
Main Authors: Qijie Zhao, Yu Jiang, Shixin Xiang, Parham Jabbarzadeh Kaboli, Jing Shen, Yueshui Zhao, Xu Wu, Fukuan Du, Mingxing Li, Chi Hin Cho, Jing Li, Qinglian Wen, Tao Liu, Tao Yi, Zhangang Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
ImmTAC
immunosuppression
immunotherapy
T-cell receptors
suicide genes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.658753/full

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