Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats
A peptic ulcer is an alimentary tract injury that leads to a mucosal defect reaching the submucosa. This work aimed to optimize and maximize ellagic acid (EA) loading in Ca pectinate floating beads to maximize the release for 24 h. Three factors were selected: Ca pectinate concentration (X1, 1–3 <...
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| Format: | Article |
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MDPI AG
2020-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/7/1006 |
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| author | Nabil A. Alhakamy Shaimaa M. Badr-Eldin Osama A. A. Ahmed Abdulrahman A. Halwani Hibah M. Aldawsari Mohamed A. El-Moselhy Aliaa Anter Sara S. Sharkawi Muhammad H. Sultan Osama A. A. Madkhali Muhammed A. Bakhrebah Mohammad N. Alomary Wesam H. Abdulaal Usama A. Fahmy |
| author_facet | Nabil A. Alhakamy Shaimaa M. Badr-Eldin Osama A. A. Ahmed Abdulrahman A. Halwani Hibah M. Aldawsari Mohamed A. El-Moselhy Aliaa Anter Sara S. Sharkawi Muhammad H. Sultan Osama A. A. Madkhali Muhammed A. Bakhrebah Mohammad N. Alomary Wesam H. Abdulaal Usama A. Fahmy |
| author_sort | Nabil A. Alhakamy |
| collection | DOAJ |
| description | A peptic ulcer is an alimentary tract injury that leads to a mucosal defect reaching the submucosa. This work aimed to optimize and maximize ellagic acid (EA) loading in Ca pectinate floating beads to maximize the release for 24 h. Three factors were selected: Ca pectinate concentration (X1, 1–3 <i>w</i>/<i>v</i> %), EA concentration (X2, 1–3 <i>w</i>/<i>v</i> %) and the dropping time (X3, 10–30 min). The factorial design proposed eight formulations. The optimized EA–Ca pectinate formulation was evaluated for the gastric ulcer index and the oxidative stress parameter determination of gastric mucosa. The results indicated that the optimum EA–Ca pectinate formula significantly improved the gastric ulcer index in comparison with raw EA. The protective effect of the optimized EA–Ca pectinate formula was further indicated by the histopathological features of the stomach. The results of the study indicate that an EA formulation in the form of Ca pectinate beads would be effective for protection against gastric ulcers because of Nonsteroidal anti-inflammatory drugs (NSAID) administration. |
| first_indexed | 2024-03-10T18:38:58Z |
| format | Article |
| id | doaj.art-dc65fd6a1e394c97a48975f72c2cfc4c |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T18:38:58Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-dc65fd6a1e394c97a48975f72c2cfc4c2023-11-20T06:00:45ZengMDPI AGBiomolecules2218-273X2020-07-01107100610.3390/biom10071006Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in RatsNabil A. Alhakamy0Shaimaa M. Badr-Eldin1Osama A. A. Ahmed2Abdulrahman A. Halwani3Hibah M. Aldawsari4Mohamed A. El-Moselhy5Aliaa Anter6Sara S. Sharkawi7Muhammad H. Sultan8Osama A. A. Madkhali9Muhammed A. Bakhrebah10Mohammad N. Alomary11Wesam H. Abdulaal12Usama A. Fahmy13Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Clinical Pharmacy and Pharmacology, Ibn Sina National College for Medical Studies, Jeddah 22413, Saudi ArabiaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minia 61519, EgyptDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minia 61519, EgyptDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi ArabiaLife Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi ArabiaLife Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi ArabiaDepartment of Biochemistry, Cancer Metabolism and Epigenetic Unit, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi ArabiaA peptic ulcer is an alimentary tract injury that leads to a mucosal defect reaching the submucosa. This work aimed to optimize and maximize ellagic acid (EA) loading in Ca pectinate floating beads to maximize the release for 24 h. Three factors were selected: Ca pectinate concentration (X1, 1–3 <i>w</i>/<i>v</i> %), EA concentration (X2, 1–3 <i>w</i>/<i>v</i> %) and the dropping time (X3, 10–30 min). The factorial design proposed eight formulations. The optimized EA–Ca pectinate formulation was evaluated for the gastric ulcer index and the oxidative stress parameter determination of gastric mucosa. The results indicated that the optimum EA–Ca pectinate formula significantly improved the gastric ulcer index in comparison with raw EA. The protective effect of the optimized EA–Ca pectinate formula was further indicated by the histopathological features of the stomach. The results of the study indicate that an EA formulation in the form of Ca pectinate beads would be effective for protection against gastric ulcers because of Nonsteroidal anti-inflammatory drugs (NSAID) administration.https://www.mdpi.com/2218-273X/10/7/1006stomatitisformulationpeptic ulcerNSAIDsfactorial designpharmacokinetics |
| spellingShingle | Nabil A. Alhakamy Shaimaa M. Badr-Eldin Osama A. A. Ahmed Abdulrahman A. Halwani Hibah M. Aldawsari Mohamed A. El-Moselhy Aliaa Anter Sara S. Sharkawi Muhammad H. Sultan Osama A. A. Madkhali Muhammed A. Bakhrebah Mohammad N. Alomary Wesam H. Abdulaal Usama A. Fahmy Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats Biomolecules stomatitis formulation peptic ulcer NSAIDs factorial design pharmacokinetics |
| title | Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats |
| title_full | Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats |
| title_fullStr | Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats |
| title_full_unstemmed | Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats |
| title_short | Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats |
| title_sort | optimized ellagic acid ca pectinate floating beads for gastroprotection against indomethacin induced gastric injury in rats |
| topic | stomatitis formulation peptic ulcer NSAIDs factorial design pharmacokinetics |
| url | https://www.mdpi.com/2218-273X/10/7/1006 |
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