Interplay between bacterial deubiquitinase and ubiquitin E3 ligase regulates ubiquitin dynamics on Legionella phagosomes

Interplay between bacterial deubiquitinase and ubiquitin E3 ligase regulates ubiquitin dynamics on Legionella phagosomes

Legionella pneumophila extensively modulates the host ubiquitin network to create the Legionella-containing vacuole (LCV) for its replication. Many of its virulence factors function as ubiquitin ligases or deubiquitinases (DUBs). Here, we identify Lem27 as a DUB that displays a preference for diubiq...

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Bibliographic Details
Main Authors: Shuxin Liu, Jiwei Luo, Xiangkai Zhen, Jiazhang Qiu, Songying Ouyang, Zhao-Qing Luo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
Legionella pneumophila
type iv secretion
bacterial virulence
otu deubiquitinase
Online Access:https://elifesciences.org/articles/58114

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