Risk factors of childhood epilepsy in Kerala
Background: We aimed to identify the risk factors for epilepsy in children. Materials and Methods: This case-control retrospective study was carried out in the pediatric neurology outpatient service of the Trivandrum Medical College. All children (1-12 years) with epilepsy satisfying the selection c...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2011-01-01
|
| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2011;volume=14;issue=4;spage=283;epage=286;aulast=Attumalil |
| _version_ | 1819138854749208576 |
|---|---|
| author | Thomas Varghese Attumalil Anil Sundaram Vivek Oommen Varghese K Vijayakumar P A Mohammed Kunju |
| author_facet | Thomas Varghese Attumalil Anil Sundaram Vivek Oommen Varghese K Vijayakumar P A Mohammed Kunju |
| author_sort | Thomas Varghese Attumalil |
| collection | DOAJ |
| description | Background: We aimed to identify the risk factors for epilepsy in children. Materials and Methods: This case-control retrospective study was carried out in the pediatric neurology outpatient service of the Trivandrum Medical College. All children (1-12 years) with epilepsy satisfying the selection criteria were included, after obtaining consent from parents. Those with single seizures or febrile seizures were excluded. Controls were children without epilepsy attending the same hospital. Parents were interviewed and clinical data were obtained from medical records. Statistical analysis included chi-square test, odds ratio (OR), and logistic regression. Results: There were 82 cases and 160 controls whose mean age was 6.9 + 3.6 and 5.2 + 3.1, years respectively. On univariate analysis, family history of epilepsy, prolonged labor, cyanosis at birth, delayed cry after birth, admission to newborn intensive care unit, presence of congenital malformations, neurocutaneous markers, incessant cry in the first week, delayed developmental milestones, meningitis, encephalitis, and head trauma were found to be significant. On logistic regression, family history of epilepsy (OR 4.7), newborn distress (OR 8.6), delayed developmental milestones (OR 12.6), and head trauma (OR 5.8) were found to be significant predictors. Infants who had history of newborn distress are likely to manifest epilepsy before 1 year if they are eventually going to have epilepsy (OR 3.4). Conclusion: Modifiable factors such as newborn distress and significant head trauma are significant risk factors for childhood epilepsy. Newborn distress is a risk factor for early-onset (<1 year age) epilepsy. |
| first_indexed | 2024-12-22T11:13:23Z |
| format | Article |
| id | doaj.art-dc669a0429ba4ad5a27e52dc8bd2a6bc |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-22T11:13:23Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-dc669a0429ba4ad5a27e52dc8bd2a6bc2022-12-21T18:28:05ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492011-01-0114428328610.4103/0972-2327.91950Risk factors of childhood epilepsy in KeralaThomas Varghese AttumalilAnil SundaramVivek Oommen VargheseK VijayakumarP A Mohammed KunjuBackground: We aimed to identify the risk factors for epilepsy in children. Materials and Methods: This case-control retrospective study was carried out in the pediatric neurology outpatient service of the Trivandrum Medical College. All children (1-12 years) with epilepsy satisfying the selection criteria were included, after obtaining consent from parents. Those with single seizures or febrile seizures were excluded. Controls were children without epilepsy attending the same hospital. Parents were interviewed and clinical data were obtained from medical records. Statistical analysis included chi-square test, odds ratio (OR), and logistic regression. Results: There were 82 cases and 160 controls whose mean age was 6.9 + 3.6 and 5.2 + 3.1, years respectively. On univariate analysis, family history of epilepsy, prolonged labor, cyanosis at birth, delayed cry after birth, admission to newborn intensive care unit, presence of congenital malformations, neurocutaneous markers, incessant cry in the first week, delayed developmental milestones, meningitis, encephalitis, and head trauma were found to be significant. On logistic regression, family history of epilepsy (OR 4.7), newborn distress (OR 8.6), delayed developmental milestones (OR 12.6), and head trauma (OR 5.8) were found to be significant predictors. Infants who had history of newborn distress are likely to manifest epilepsy before 1 year if they are eventually going to have epilepsy (OR 3.4). Conclusion: Modifiable factors such as newborn distress and significant head trauma are significant risk factors for childhood epilepsy. Newborn distress is a risk factor for early-onset (<1 year age) epilepsy.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2011;volume=14;issue=4;spage=283;epage=286;aulast=AttumalilEpilepsyKeralarisk factor |
| spellingShingle | Thomas Varghese Attumalil Anil Sundaram Vivek Oommen Varghese K Vijayakumar P A Mohammed Kunju Risk factors of childhood epilepsy in Kerala Annals of Indian Academy of Neurology Epilepsy Kerala risk factor |
| title | Risk factors of childhood epilepsy in Kerala |
| title_full | Risk factors of childhood epilepsy in Kerala |
| title_fullStr | Risk factors of childhood epilepsy in Kerala |
| title_full_unstemmed | Risk factors of childhood epilepsy in Kerala |
| title_short | Risk factors of childhood epilepsy in Kerala |
| title_sort | risk factors of childhood epilepsy in kerala |
| topic | Epilepsy Kerala risk factor |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2011;volume=14;issue=4;spage=283;epage=286;aulast=Attumalil |
| work_keys_str_mv | AT thomasvargheseattumalil riskfactorsofchildhoodepilepsyinkerala AT anilsundaram riskfactorsofchildhoodepilepsyinkerala AT vivekoommenvarghese riskfactorsofchildhoodepilepsyinkerala AT kvijayakumar riskfactorsofchildhoodepilepsyinkerala AT pamohammedkunju riskfactorsofchildhoodepilepsyinkerala |