Scalloping of the Liver and Spleen on Preoperative CT-Scan of Pseudomyxoma Peritonei Patients: Impact on Prediction of Resectability, Grade, Morbidity and Survival
Pseudomyxoma peritonei (PMP) is ideally treated by cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC), leading to significant morbidity. Beyond the histologic grade, the prognosis lies in the completeness of cytoreduction (CC-score of 0/1 vs. 2/3) and the severe compl...
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| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/18/4434 |
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| author | Vahan Kepenekian Amaniel Kefleyesus David Keskin Nazim Benzerdjeb Isabelle Bonnefoy Laurent Villeneuve Omar Alhadeedi Abeer Al-Otaibi Alexandre Galan Olivier Glehen Julien Péron Pascal Rousset |
| author_facet | Vahan Kepenekian Amaniel Kefleyesus David Keskin Nazim Benzerdjeb Isabelle Bonnefoy Laurent Villeneuve Omar Alhadeedi Abeer Al-Otaibi Alexandre Galan Olivier Glehen Julien Péron Pascal Rousset |
| author_sort | Vahan Kepenekian |
| collection | DOAJ |
| description | Pseudomyxoma peritonei (PMP) is ideally treated by cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC), leading to significant morbidity. Beyond the histologic grade, the prognosis lies in the completeness of cytoreduction (CC-score of 0/1 vs. 2/3) and the severe complication rate. The mucinous nature of the peritoneal implants sometimes induces liver and/or spleen scalloping on imaging. The predictive value of scalloping was assessed regarding resectability, grade, survival and severe morbidity. This monocentric, retrospective analysis compared CC-0/1 with CC-2/3 groups regarding liver and spleen scalloping parameters, assessed on pre-operative computed tomography (CT) scan, reviewed for the study. In addition, prognostic factors of severe complications and recurrence-free and overall survivals were explored in the CC-0/1 population. Overall, 129 patients were included (109 CC-0/1, 20 CC-2/3), with 58 (45%) exhibiting scalloping. All patients with splenic scalloping also had a liver one. Scalloping was more frequent (75% vs. 39%), with greater median maximal depth (21 vs. 11 mm) and higher PCI (32 vs. 14) in the CC-2/3 population, but was not predictive of either grade or survival. In CC-0/1 patients, survivals and postoperative complications were not affected by scalloping parameters. Scalloping appeared as a marker of advanced PMP, but was not predictive of grade, severe complications, or long-term outcomes. |
| first_indexed | 2024-03-10T00:30:02Z |
| format | Article |
| id | doaj.art-dc67d900c6a14050a71ad62e2374821c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:30:02Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-dc67d900c6a14050a71ad62e2374821c2023-11-23T15:27:13ZengMDPI AGCancers2072-66942022-09-011418443410.3390/cancers14184434Scalloping of the Liver and Spleen on Preoperative CT-Scan of Pseudomyxoma Peritonei Patients: Impact on Prediction of Resectability, Grade, Morbidity and SurvivalVahan Kepenekian0Amaniel Kefleyesus1David Keskin2Nazim Benzerdjeb3Isabelle Bonnefoy4Laurent Villeneuve5Omar Alhadeedi6Abeer Al-Otaibi7Alexandre Galan8Olivier Glehen9Julien Péron10Pascal Rousset11Surgical Oncology Department, Hôpital Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, FranceSurgical Oncology Department, Hôpital Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, FranceDepartment of Radiology, Hôpital Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, FranceCICLY-EA3738, Université Claude Bernard Lyon I (UCBL1), 69622 Lyon, FranceSurgical Oncology Department, Hôpital Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, FranceSurgical Oncology Department, Hôpital Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, FranceSurgical Oncology Department, Hôpital Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, FranceDepartment of Radiology, Hôpital Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, FranceDepartment of Radiology, Hôpital Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, FranceSurgical Oncology Department, Hôpital Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, FranceMedical Oncology Department, Hôpital Lyon Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, FranceCICLY-EA3738, Université Claude Bernard Lyon I (UCBL1), 69622 Lyon, FrancePseudomyxoma peritonei (PMP) is ideally treated by cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC), leading to significant morbidity. Beyond the histologic grade, the prognosis lies in the completeness of cytoreduction (CC-score of 0/1 vs. 2/3) and the severe complication rate. The mucinous nature of the peritoneal implants sometimes induces liver and/or spleen scalloping on imaging. The predictive value of scalloping was assessed regarding resectability, grade, survival and severe morbidity. This monocentric, retrospective analysis compared CC-0/1 with CC-2/3 groups regarding liver and spleen scalloping parameters, assessed on pre-operative computed tomography (CT) scan, reviewed for the study. In addition, prognostic factors of severe complications and recurrence-free and overall survivals were explored in the CC-0/1 population. Overall, 129 patients were included (109 CC-0/1, 20 CC-2/3), with 58 (45%) exhibiting scalloping. All patients with splenic scalloping also had a liver one. Scalloping was more frequent (75% vs. 39%), with greater median maximal depth (21 vs. 11 mm) and higher PCI (32 vs. 14) in the CC-2/3 population, but was not predictive of either grade or survival. In CC-0/1 patients, survivals and postoperative complications were not affected by scalloping parameters. Scalloping appeared as a marker of advanced PMP, but was not predictive of grade, severe complications, or long-term outcomes.https://www.mdpi.com/2072-6694/14/18/4434pseudomyxoma peritonei (PMP)scallopingresectabilityprognostic factorrecurrence predictionsevere complications prediction |
| spellingShingle | Vahan Kepenekian Amaniel Kefleyesus David Keskin Nazim Benzerdjeb Isabelle Bonnefoy Laurent Villeneuve Omar Alhadeedi Abeer Al-Otaibi Alexandre Galan Olivier Glehen Julien Péron Pascal Rousset Scalloping of the Liver and Spleen on Preoperative CT-Scan of Pseudomyxoma Peritonei Patients: Impact on Prediction of Resectability, Grade, Morbidity and Survival Cancers pseudomyxoma peritonei (PMP) scalloping resectability prognostic factor recurrence prediction severe complications prediction |
| title | Scalloping of the Liver and Spleen on Preoperative CT-Scan of Pseudomyxoma Peritonei Patients: Impact on Prediction of Resectability, Grade, Morbidity and Survival |
| title_full | Scalloping of the Liver and Spleen on Preoperative CT-Scan of Pseudomyxoma Peritonei Patients: Impact on Prediction of Resectability, Grade, Morbidity and Survival |
| title_fullStr | Scalloping of the Liver and Spleen on Preoperative CT-Scan of Pseudomyxoma Peritonei Patients: Impact on Prediction of Resectability, Grade, Morbidity and Survival |
| title_full_unstemmed | Scalloping of the Liver and Spleen on Preoperative CT-Scan of Pseudomyxoma Peritonei Patients: Impact on Prediction of Resectability, Grade, Morbidity and Survival |
| title_short | Scalloping of the Liver and Spleen on Preoperative CT-Scan of Pseudomyxoma Peritonei Patients: Impact on Prediction of Resectability, Grade, Morbidity and Survival |
| title_sort | scalloping of the liver and spleen on preoperative ct scan of pseudomyxoma peritonei patients impact on prediction of resectability grade morbidity and survival |
| topic | pseudomyxoma peritonei (PMP) scalloping resectability prognostic factor recurrence prediction severe complications prediction |
| url | https://www.mdpi.com/2072-6694/14/18/4434 |
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