Research progress of RhoGTPase activating protein in epithelial-mesenchymal transition
Epithelial-mesenchymal transition (EMT) is a process by which epithelial cells undergo morphological changes to gain a mesenchymal cell phenotype and migratory properties. As a class of negative regulators of RhoGTPases, RhoGTPase activating proteins(RhoGAP) can bridge between cell surface receptors...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2023-02-01
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| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-2-301.pdf |
| _version_ | 1797366387907231744 |
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| author | XU Qian, DUAN Hua, GAN Lu, LIU Qiwei |
| author_facet | XU Qian, DUAN Hua, GAN Lu, LIU Qiwei |
| author_sort | XU Qian, DUAN Hua, GAN Lu, LIU Qiwei |
| collection | DOAJ |
| description | Epithelial-mesenchymal transition (EMT) is a process by which epithelial cells undergo morphological changes to gain a mesenchymal cell phenotype and migratory properties. As a class of negative regulators of RhoGTPases, RhoGTPase activating proteins(RhoGAP) can bridge between cell surface receptors and cellular actin cytoskeleton during EMT procedure, which may influence cancer cell transition and outcome of fibrotic diseases and may help search for anti-tumor and anti-fibrotic managements. |
| first_indexed | 2024-03-08T17:03:26Z |
| format | Article |
| id | doaj.art-dc696e17e2be4a699d97c60cd9fd5048 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T17:03:26Z |
| publishDate | 2023-02-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-dc696e17e2be4a699d97c60cd9fd50482024-01-04T07:27:29ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252023-02-0143230130510.16352/j.issn.1001-6325.2023.02.301Research progress of RhoGTPase activating protein in epithelial-mesenchymal transitionXU Qian, DUAN Hua, GAN Lu, LIU Qiwei0Department of Gynecology Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100006, ChinaEpithelial-mesenchymal transition (EMT) is a process by which epithelial cells undergo morphological changes to gain a mesenchymal cell phenotype and migratory properties. As a class of negative regulators of RhoGTPases, RhoGTPase activating proteins(RhoGAP) can bridge between cell surface receptors and cellular actin cytoskeleton during EMT procedure, which may influence cancer cell transition and outcome of fibrotic diseases and may help search for anti-tumor and anti-fibrotic managements.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-2-301.pdfrhogtpase activating protein|epithelial-mesenchymal transition|actin cytoskeleton|metastasis|fibrotic diseases |
| spellingShingle | XU Qian, DUAN Hua, GAN Lu, LIU Qiwei Research progress of RhoGTPase activating protein in epithelial-mesenchymal transition Jichu yixue yu linchuang rhogtpase activating protein|epithelial-mesenchymal transition|actin cytoskeleton|metastasis|fibrotic diseases |
| title | Research progress of RhoGTPase activating protein in epithelial-mesenchymal transition |
| title_full | Research progress of RhoGTPase activating protein in epithelial-mesenchymal transition |
| title_fullStr | Research progress of RhoGTPase activating protein in epithelial-mesenchymal transition |
| title_full_unstemmed | Research progress of RhoGTPase activating protein in epithelial-mesenchymal transition |
| title_short | Research progress of RhoGTPase activating protein in epithelial-mesenchymal transition |
| title_sort | research progress of rhogtpase activating protein in epithelial mesenchymal transition |
| topic | rhogtpase activating protein|epithelial-mesenchymal transition|actin cytoskeleton|metastasis|fibrotic diseases |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-2-301.pdf |
| work_keys_str_mv | AT xuqianduanhuaganluliuqiwei researchprogressofrhogtpaseactivatingproteininepithelialmesenchymaltransition |