Influence of trimetazidine on myocardium energy balance during chemotherapy with doxorubicin and cyclophosphamide

Aim of the study was to assess the degree of myocardial ischemia in rats on chronic in vivo model, with a simultaneous assessment of justification for the use of trimetazidine. Material and methods. The object of the study was 120 male inbred Wistar rats, randomly divided into 4 equal groups: group...

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Main Author: A. A. Avagimyan
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Siberian Branch Publishing House 2022-06-01
Series:Сибирский научный медицинский журнал
Subjects:
Online Access:https://sibmed.elpub.ru/jour/article/view/802
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author A. A. Avagimyan
author_facet A. A. Avagimyan
author_sort A. A. Avagimyan
collection DOAJ
description Aim of the study was to assess the degree of myocardial ischemia in rats on chronic in vivo model, with a simultaneous assessment of justification for the use of trimetazidine. Material and methods. The object of the study was 120 male inbred Wistar rats, randomly divided into 4 equal groups: group 1 – control (administration of 0.9% sodium chloride solution 3 times a week); group 2 – simulation of the AC chemotherapy regimen by intraperitoneal administration of doxorubicin hydrochloride at a single dose of 2.5 mg/kg and cyclophosphamide monohydrate at a single dose of 25 mg/kg 3 times a week; group 3 – simulation of the AC chemotherapy regimen with additional administration of trimetazidine dihydrochloride daily by intragastric gavage at a single dose of 3.0 mg/kg; group 4 – administration of trimetazidine dihydrochloride. The study has been carried out for two weeks. An Olympus IX51 microscope was used to assess the changes. Staining was carried out by the HBFP method (hematoxylin + basic fuchsin + picronic acid). Results and discussion. In group 2, on the background of AC chemotherapy, the level of fuchsinophilia in myocardial tissue was 87.2 and 90.9 % higher (p < 0.05) than in groups 1 and 4, respectively, the specific area of damage was 170.8 and 167. 5 %, respectively (p < 0.05). In group 3, the severity of fuchsinophilia and the specific area of myocardial damage were statistically significantly less (by 26.3 and 36.5 %, p < 0.05) than in group 2. Conclusions. Trimetazidine is a pathogenetically effective drug that protects the myocardium from damage associated with AC chemotherapy.
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spelling doaj.art-dc69fd3e051342b0a0f05f4b7f10edc42024-03-07T18:50:00ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202022-06-0142310.18699/SSMJ20220304422Influence of trimetazidine on myocardium energy balance during chemotherapy with doxorubicin and cyclophosphamideA. A. Avagimyan0Yerevan State Medical University Mh. Heratsi Republic of Armenia; A.P. Avtsyn Research Institute of Human MorphologyAim of the study was to assess the degree of myocardial ischemia in rats on chronic in vivo model, with a simultaneous assessment of justification for the use of trimetazidine. Material and methods. The object of the study was 120 male inbred Wistar rats, randomly divided into 4 equal groups: group 1 – control (administration of 0.9% sodium chloride solution 3 times a week); group 2 – simulation of the AC chemotherapy regimen by intraperitoneal administration of doxorubicin hydrochloride at a single dose of 2.5 mg/kg and cyclophosphamide monohydrate at a single dose of 25 mg/kg 3 times a week; group 3 – simulation of the AC chemotherapy regimen with additional administration of trimetazidine dihydrochloride daily by intragastric gavage at a single dose of 3.0 mg/kg; group 4 – administration of trimetazidine dihydrochloride. The study has been carried out for two weeks. An Olympus IX51 microscope was used to assess the changes. Staining was carried out by the HBFP method (hematoxylin + basic fuchsin + picronic acid). Results and discussion. In group 2, on the background of AC chemotherapy, the level of fuchsinophilia in myocardial tissue was 87.2 and 90.9 % higher (p < 0.05) than in groups 1 and 4, respectively, the specific area of damage was 170.8 and 167. 5 %, respectively (p < 0.05). In group 3, the severity of fuchsinophilia and the specific area of myocardial damage were statistically significantly less (by 26.3 and 36.5 %, p < 0.05) than in group 2. Conclusions. Trimetazidine is a pathogenetically effective drug that protects the myocardium from damage associated with AC chemotherapy.https://sibmed.elpub.ru/jour/article/view/802doxorubicincyclophosphamidecardiotoxicitychemotherapycardio-oncology
spellingShingle A. A. Avagimyan
Influence of trimetazidine on myocardium energy balance during chemotherapy with doxorubicin and cyclophosphamide
Сибирский научный медицинский журнал
doxorubicin
cyclophosphamide
cardiotoxicity
chemotherapy
cardio-oncology
title Influence of trimetazidine on myocardium energy balance during chemotherapy with doxorubicin and cyclophosphamide
title_full Influence of trimetazidine on myocardium energy balance during chemotherapy with doxorubicin and cyclophosphamide
title_fullStr Influence of trimetazidine on myocardium energy balance during chemotherapy with doxorubicin and cyclophosphamide
title_full_unstemmed Influence of trimetazidine on myocardium energy balance during chemotherapy with doxorubicin and cyclophosphamide
title_short Influence of trimetazidine on myocardium energy balance during chemotherapy with doxorubicin and cyclophosphamide
title_sort influence of trimetazidine on myocardium energy balance during chemotherapy with doxorubicin and cyclophosphamide
topic doxorubicin
cyclophosphamide
cardiotoxicity
chemotherapy
cardio-oncology
url https://sibmed.elpub.ru/jour/article/view/802
work_keys_str_mv AT aaavagimyan influenceoftrimetazidineonmyocardiumenergybalanceduringchemotherapywithdoxorubicinandcyclophosphamide