Ceramides: focus on obesity
It is generally known that obesity increases the risk of developing cardiovascular disease. A pathological increase in the mass of adipose tissue leads to a violation of the control of lipid accumulation at the molecular level, abnormal lipid metabolism with the formation of metabolites, which are c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Endocrinology Research Centre
2020-12-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/12565 |
| _version_ | 1797204635830714368 |
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| author | Yulia A. Dyleva Olga V. Gruzdeva Ekaterina V. Belik |
| author_facet | Yulia A. Dyleva Olga V. Gruzdeva Ekaterina V. Belik |
| author_sort | Yulia A. Dyleva |
| collection | DOAJ |
| description | It is generally known that obesity increases the risk of developing cardiovascular disease. A pathological increase in the mass of adipose tissue leads to a violation of the control of lipid accumulation at the molecular level, abnormal lipid metabolism with the formation of metabolites, which are critical for the development of these pathologies against the background of obesity. Ceramides are one of these metabolites. Ceramides perform many physiological functions, but under pathological conditions they induce insulin resistance, uncouple cellular respiration and phosphorylation, activate cell apoptosis, and play an important role in the induction of adipose tissue dysfunction. Altering ceramide biosynthesis through dysregulation of key enzymes leads to the formation and accumulation of ceramides, which block insulin signaling and induce adipose tissue inflammation.This review highlights the metabolism of ceramides, the reasons for their ectopic deposition in tissues in obesity, as well as potential intracellular signaling pathways that modulate ceramide activity. |
| first_indexed | 2024-03-08T09:12:40Z |
| format | Article |
| id | doaj.art-dc6c9f67f54642c499ec3fa316ea17ae |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:38:22Z |
| publishDate | 2020-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-dc6c9f67f54642c499ec3fa316ea17ae2024-04-16T16:16:12ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242020-12-0117330731510.14341/omet1256510853Ceramides: focus on obesityYulia A. Dyleva0Olga V. Gruzdeva1Ekaterina V. Belik2Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular DiseasesFederal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular DiseasesFederal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular DiseasesIt is generally known that obesity increases the risk of developing cardiovascular disease. A pathological increase in the mass of adipose tissue leads to a violation of the control of lipid accumulation at the molecular level, abnormal lipid metabolism with the formation of metabolites, which are critical for the development of these pathologies against the background of obesity. Ceramides are one of these metabolites. Ceramides perform many physiological functions, but under pathological conditions they induce insulin resistance, uncouple cellular respiration and phosphorylation, activate cell apoptosis, and play an important role in the induction of adipose tissue dysfunction. Altering ceramide biosynthesis through dysregulation of key enzymes leads to the formation and accumulation of ceramides, which block insulin signaling and induce adipose tissue inflammation.This review highlights the metabolism of ceramides, the reasons for their ectopic deposition in tissues in obesity, as well as potential intracellular signaling pathways that modulate ceramide activity.https://www.omet-endojournals.ru/jour/article/view/12565ceramidesphingolipidsobesity |
| spellingShingle | Yulia A. Dyleva Olga V. Gruzdeva Ekaterina V. Belik Ceramides: focus on obesity Ожирение и метаболизм ceramide sphingolipids obesity |
| title | Ceramides: focus on obesity |
| title_full | Ceramides: focus on obesity |
| title_fullStr | Ceramides: focus on obesity |
| title_full_unstemmed | Ceramides: focus on obesity |
| title_short | Ceramides: focus on obesity |
| title_sort | ceramides focus on obesity |
| topic | ceramide sphingolipids obesity |
| url | https://www.omet-endojournals.ru/jour/article/view/12565 |
| work_keys_str_mv | AT yuliaadyleva ceramidesfocusonobesity AT olgavgruzdeva ceramidesfocusonobesity AT ekaterinavbelik ceramidesfocusonobesity |