Multimodal OCT Control for Early Histological Signs of Vulvar Lichen Sclerosus Recurrence after Systemic PDT: Pilot Study
Photodynamic therapy (PDT) is a modern treatment for severe or treatment-resistant vulvar lichen sclerosus (VLS). The chronic and recurrent nature of VLS requires control of recurrences at an early stage. In this paper, a non-invasive multimodal optical coherence tomography (OCT) method was used to...
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/13967 |
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| author | Arseniy Potapov Lev Matveev Alexander Moiseev Elena Sedova Maria Loginova Maria Karabut Irina Kuznetsova Viktoriya Levchenko Elena Grebenkina Sergey Gamayunov Stefka Radenska-Lopovok Marina Sirotkina Natalia Gladkova |
| author_facet | Arseniy Potapov Lev Matveev Alexander Moiseev Elena Sedova Maria Loginova Maria Karabut Irina Kuznetsova Viktoriya Levchenko Elena Grebenkina Sergey Gamayunov Stefka Radenska-Lopovok Marina Sirotkina Natalia Gladkova |
| author_sort | Arseniy Potapov |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is a modern treatment for severe or treatment-resistant vulvar lichen sclerosus (VLS). The chronic and recurrent nature of VLS requires control of recurrences at an early stage. In this paper, a non-invasive multimodal optical coherence tomography (OCT) method was used to control for early histological signs of VLS recurrence after systemic PDT using Photodithazine<sup>®</sup>. To interpret the OCT data, a histological examination was performed before PDT and 3 months after PDT. Two groups of patients were identified: with early histological signs of VLS recurrence (Group I, <i>n</i> = 5) and without histological signs of VLS recurrence (Group II, <i>n</i> = 6). We use structural OCT, OCT angiography, and OCT lymphangiography throughout 6 months after PDT to visually assess the skin components and to quantitatively assess the dermis by calculating the depth-resolved attenuation coefficient and the density of blood and lymphatic vessels. The OCT data assessment showed a statistically significant difference between the patient groups 3 months after PDT. In Group II, all the studied OCT parameters reached maximum values by the 3rd month after PDT, which indicated recovery of the skin structure. At the same time, in Group I, the values of OCT parameters did not approach the values those in Group II even after 6 months. The obtained results of multimodal OCT can be used for non-invasive control of early histological recurrence of VLS after systemic PDT and for adjusting treatment tactics in advance, without waiting for new clinical manifestations of the disease. |
| first_indexed | 2024-03-10T22:40:41Z |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:40:41Z |
| publishDate | 2023-09-01 |
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| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dc6ccdf704b04212b27ed955a2ec87282023-11-19T11:05:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181396710.3390/ijms241813967Multimodal OCT Control for Early Histological Signs of Vulvar Lichen Sclerosus Recurrence after Systemic PDT: Pilot StudyArseniy Potapov0Lev Matveev1Alexander Moiseev2Elena Sedova3Maria Loginova4Maria Karabut5Irina Kuznetsova6Viktoriya Levchenko7Elena Grebenkina8Sergey Gamayunov9Stefka Radenska-Lopovok10Marina Sirotkina11Natalia Gladkova12Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, RussiaInstitute of Applied Physics Russian Academy of Sciences, 603950 Nizhny Novgorod, RussiaInstitute of Applied Physics Russian Academy of Sciences, 603950 Nizhny Novgorod, RussiaNizhny Novgorod Regional Oncologic Hospital, 603126 Nizhny Novgorod, RussiaInstitute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, RussiaInstitute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, RussiaDepartment of Obstetrics and Gynecology, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, RussiaNizhny Novgorod Regional Oncologic Hospital, 603126 Nizhny Novgorod, RussiaNizhny Novgorod Regional Oncologic Hospital, 603126 Nizhny Novgorod, RussiaNizhny Novgorod Regional Oncologic Hospital, 603126 Nizhny Novgorod, RussiaInstitute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, RussiaInstitute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, RussiaInstitute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, RussiaPhotodynamic therapy (PDT) is a modern treatment for severe or treatment-resistant vulvar lichen sclerosus (VLS). The chronic and recurrent nature of VLS requires control of recurrences at an early stage. In this paper, a non-invasive multimodal optical coherence tomography (OCT) method was used to control for early histological signs of VLS recurrence after systemic PDT using Photodithazine<sup>®</sup>. To interpret the OCT data, a histological examination was performed before PDT and 3 months after PDT. Two groups of patients were identified: with early histological signs of VLS recurrence (Group I, <i>n</i> = 5) and without histological signs of VLS recurrence (Group II, <i>n</i> = 6). We use structural OCT, OCT angiography, and OCT lymphangiography throughout 6 months after PDT to visually assess the skin components and to quantitatively assess the dermis by calculating the depth-resolved attenuation coefficient and the density of blood and lymphatic vessels. The OCT data assessment showed a statistically significant difference between the patient groups 3 months after PDT. In Group II, all the studied OCT parameters reached maximum values by the 3rd month after PDT, which indicated recovery of the skin structure. At the same time, in Group I, the values of OCT parameters did not approach the values those in Group II even after 6 months. The obtained results of multimodal OCT can be used for non-invasive control of early histological recurrence of VLS after systemic PDT and for adjusting treatment tactics in advance, without waiting for new clinical manifestations of the disease.https://www.mdpi.com/1422-0067/24/18/13967vulva lichen sclerosussystemic photodynamic therapymultimodal optical coherence tomographystructural OCTOCT angiographyOCT lymphangiography |
| spellingShingle | Arseniy Potapov Lev Matveev Alexander Moiseev Elena Sedova Maria Loginova Maria Karabut Irina Kuznetsova Viktoriya Levchenko Elena Grebenkina Sergey Gamayunov Stefka Radenska-Lopovok Marina Sirotkina Natalia Gladkova Multimodal OCT Control for Early Histological Signs of Vulvar Lichen Sclerosus Recurrence after Systemic PDT: Pilot Study International Journal of Molecular Sciences vulva lichen sclerosus systemic photodynamic therapy multimodal optical coherence tomography structural OCT OCT angiography OCT lymphangiography |
| title | Multimodal OCT Control for Early Histological Signs of Vulvar Lichen Sclerosus Recurrence after Systemic PDT: Pilot Study |
| title_full | Multimodal OCT Control for Early Histological Signs of Vulvar Lichen Sclerosus Recurrence after Systemic PDT: Pilot Study |
| title_fullStr | Multimodal OCT Control for Early Histological Signs of Vulvar Lichen Sclerosus Recurrence after Systemic PDT: Pilot Study |
| title_full_unstemmed | Multimodal OCT Control for Early Histological Signs of Vulvar Lichen Sclerosus Recurrence after Systemic PDT: Pilot Study |
| title_short | Multimodal OCT Control for Early Histological Signs of Vulvar Lichen Sclerosus Recurrence after Systemic PDT: Pilot Study |
| title_sort | multimodal oct control for early histological signs of vulvar lichen sclerosus recurrence after systemic pdt pilot study |
| topic | vulva lichen sclerosus systemic photodynamic therapy multimodal optical coherence tomography structural OCT OCT angiography OCT lymphangiography |
| url | https://www.mdpi.com/1422-0067/24/18/13967 |
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