Miniaturized Bioaffinity Assessment Coupled to Mass Spectrometry for Guided Purification of Bioactives from Toad and Cone Snail

Miniaturized Bioaffinity Assessment Coupled to Mass Spectrometry for Guided Purification of Bioactives from Toad and Cone Snail

A nano-flow high-resolution screening platform, featuring a parallel chip-based microfluidic bioassay and mass spectrometry coupled to nano-liquid chromatography, was applied to screen animal venoms for nicotinic acetylcholine receptor like (nAChR) affinity by using the acetylcholine binding protein...

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Detalles Bibliográficos
Autores principales: Ferry Heus, Reka A. Otvos, Ruud L. E. G. Aspers, Rene van Elk, Jenny I. Halff, Andreas W. Ehlers, Sébastien Dutertre, Richard J. Lewis, Sybren Wijmenga, August B. Smit, Wilfried M. A. Niessen, Jeroen Kool
Formato: Artículo
Lenguaje:English
Publicado: MDPI AG 2014-02-01
Colección:Biology
Materias:
on-line microfluidics
nano-liquid chromatography-mass spectrometry (nano-LC-MS)
Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP)
Conus textile
Bufo alvarius
Bufo marinus
Acceso en línea:http://www.mdpi.com/2079-7737/3/1/139

Internet

http://www.mdpi.com/2079-7737/3/1/139

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