Miniaturized Bioaffinity Assessment Coupled to Mass Spectrometry for Guided Purification of Bioactives from Toad and Cone Snail

Miniaturized Bioaffinity Assessment Coupled to Mass Spectrometry for Guided Purification of Bioactives from Toad and Cone Snail

A nano-flow high-resolution screening platform, featuring a parallel chip-based microfluidic bioassay and mass spectrometry coupled to nano-liquid chromatography, was applied to screen animal venoms for nicotinic acetylcholine receptor like (nAChR) affinity by using the acetylcholine binding protein...

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Detalles Bibliográficos
Main Authors:	Ferry Heus, Reka A. Otvos, Ruud L. E. G. Aspers, Rene van Elk, Jenny I. Halff, Andreas W. Ehlers, Sébastien Dutertre, Richard J. Lewis, Sybren Wijmenga, August B. Smit, Wilfried M. A. Niessen, Jeroen Kool
Formato:	Artigo
Idioma:	English
Publicado:	MDPI AG 2014-02-01
Series:	Biology
Subjects:	on-line microfluidics nano-liquid chromatography-mass spectrometry (nano-LC-MS) Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP) Conus textile Bufo alvarius Bufo marinus
Acceso en liña:	http://www.mdpi.com/2079-7737/3/1/139

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