Miniaturized Bioaffinity Assessment Coupled to Mass Spectrometry for Guided Purification of Bioactives from Toad and Cone Snail

Miniaturized Bioaffinity Assessment Coupled to Mass Spectrometry for Guided Purification of Bioactives from Toad and Cone Snail

A nano-flow high-resolution screening platform, featuring a parallel chip-based microfluidic bioassay and mass spectrometry coupled to nano-liquid chromatography, was applied to screen animal venoms for nicotinic acetylcholine receptor like (nAChR) affinity by using the acetylcholine binding protein...

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Dettagli Bibliografici
Autori principali:	Ferry Heus, Reka A. Otvos, Ruud L. E. G. Aspers, Rene van Elk, Jenny I. Halff, Andreas W. Ehlers, Sébastien Dutertre, Richard J. Lewis, Sybren Wijmenga, August B. Smit, Wilfried M. A. Niessen, Jeroen Kool
Natura:	Articolo
Lingua:	English
Pubblicazione:	MDPI AG 2014-02-01
Serie:	Biology
Soggetti:	on-line microfluidics nano-liquid chromatography-mass spectrometry (nano-LC-MS) Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP) Conus textile Bufo alvarius Bufo marinus
Accesso online:	http://www.mdpi.com/2079-7737/3/1/139

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