Modern treatment options for mixed and aerobic vaginitis
Mixed vaginitis is closely associated with an increased risk of pelvic inflammatory disease, reproductive failures, preterm births, postpartum infectious and inflammatory complications, and cervical neoplasiae. The article considers the main issues of diagnosis and treatment of the disease, mainly c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2022-04-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/6803 |
| _version_ | 1797842201348145152 |
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| author | I. A. Apolikhina E. A. Gorbunova Z. N. Efendieva |
| author_facet | I. A. Apolikhina E. A. Gorbunova Z. N. Efendieva |
| author_sort | I. A. Apolikhina |
| collection | DOAJ |
| description | Mixed vaginitis is closely associated with an increased risk of pelvic inflammatory disease, reproductive failures, preterm births, postpartum infectious and inflammatory complications, and cervical neoplasiae. The article considers the main issues of diagnosis and treatment of the disease, mainly caused by the polyetiological nature of mixed vaginitis and relapse tendencies. Effective techniques of integrated approach and impact on all etiological agents of mixed vaginitis with a minimal effect on the normal vaginal microflora are presented. In the modern obstetrics-gynecology practice, preference is given to combination drugs intended for topical use, and a rational choice of the dosage form ensures maximum patient compliance and treatment efficiency. It is topical dosage forms that contribute to the rapid delivery of the active substance to the inflammation site and do not have systemic effects characteristic of oral dosage forms. A new domestic multicomponent drug to treat vaginitis and prevent its development has been provided a market authorization on the Russian market. Its action is ensured by combined effects of the components in its composition, such as metronidazole (500 mg), chloramphenicol (200 mg), natamycin (150 mg), hydrocortisone acetate (15 mg), due to which the drug provides a wide range of etiotropic and symptomatic effects. The article presents the results of comparative clinical studies on assessment of the efficacy, tolerability and safety of the drug in the treatment of vulvovaginitis of mixed etiology. The Russian studies showed that this combination provides a minimal risk of systemic effects and the most favourable safety and tolerability profile of therapy as compared to the oral dosage forms, which gives grounds to recommend it for use in the clinical obstetrics-gynecology practice. |
| first_indexed | 2024-04-09T16:43:58Z |
| format | Article |
| id | doaj.art-dc6d6eff98144c79abe0430574e3a61a |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:43:58Z |
| publishDate | 2022-04-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-dc6d6eff98144c79abe0430574e3a61a2023-04-23T06:56:33ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902022-04-010513714310.21518/2079-701X-2022-16-5-137-1436111Modern treatment options for mixed and aerobic vaginitisI. A. Apolikhina0E. A. Gorbunova1Z. N. Efendieva2Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology; Institute for Professional Education at Sechenov First Moscow State Medical UniversityKulakov National Medical Research Center of Obstetrics, Gynecology and PerinatologyKulakov National Medical Research Center of Obstetrics, Gynecology and PerinatologyMixed vaginitis is closely associated with an increased risk of pelvic inflammatory disease, reproductive failures, preterm births, postpartum infectious and inflammatory complications, and cervical neoplasiae. The article considers the main issues of diagnosis and treatment of the disease, mainly caused by the polyetiological nature of mixed vaginitis and relapse tendencies. Effective techniques of integrated approach and impact on all etiological agents of mixed vaginitis with a minimal effect on the normal vaginal microflora are presented. In the modern obstetrics-gynecology practice, preference is given to combination drugs intended for topical use, and a rational choice of the dosage form ensures maximum patient compliance and treatment efficiency. It is topical dosage forms that contribute to the rapid delivery of the active substance to the inflammation site and do not have systemic effects characteristic of oral dosage forms. A new domestic multicomponent drug to treat vaginitis and prevent its development has been provided a market authorization on the Russian market. Its action is ensured by combined effects of the components in its composition, such as metronidazole (500 mg), chloramphenicol (200 mg), natamycin (150 mg), hydrocortisone acetate (15 mg), due to which the drug provides a wide range of etiotropic and symptomatic effects. The article presents the results of comparative clinical studies on assessment of the efficacy, tolerability and safety of the drug in the treatment of vulvovaginitis of mixed etiology. The Russian studies showed that this combination provides a minimal risk of systemic effects and the most favourable safety and tolerability profile of therapy as compared to the oral dosage forms, which gives grounds to recommend it for use in the clinical obstetrics-gynecology practice.https://www.med-sovet.pro/jour/article/view/6803сmixed vaginitismetronidazolebacteriacandida fungiaerobic vaginitis |
| spellingShingle | I. A. Apolikhina E. A. Gorbunova Z. N. Efendieva Modern treatment options for mixed and aerobic vaginitis Медицинский совет сmixed vaginitis metronidazole bacteria candida fungi aerobic vaginitis |
| title | Modern treatment options for mixed and aerobic vaginitis |
| title_full | Modern treatment options for mixed and aerobic vaginitis |
| title_fullStr | Modern treatment options for mixed and aerobic vaginitis |
| title_full_unstemmed | Modern treatment options for mixed and aerobic vaginitis |
| title_short | Modern treatment options for mixed and aerobic vaginitis |
| title_sort | modern treatment options for mixed and aerobic vaginitis |
| topic | сmixed vaginitis metronidazole bacteria candida fungi aerobic vaginitis |
| url | https://www.med-sovet.pro/jour/article/view/6803 |
| work_keys_str_mv | AT iaapolikhina moderntreatmentoptionsformixedandaerobicvaginitis AT eagorbunova moderntreatmentoptionsformixedandaerobicvaginitis AT znefendieva moderntreatmentoptionsformixedandaerobicvaginitis |