Fructose Causes Liver Damage, Polyploidy, and Dysplasia in the Setting of Short Telomeres and p53 Loss

Fructose Causes Liver Damage, Polyploidy, and Dysplasia in the Setting of Short Telomeres and p53 Loss

Studies in humans and model systems have established an important role of short telomeres in predisposing to liver fibrosis through pathways that are incompletely understood. Recent studies have shown that telomere dysfunction impairs cellular metabolism, but whether and how these metabolic alterati...

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Bibliographic Details
Main Authors: Christopher Chronowski, Viktor Akhanov, Doug Chan, Andre Catic, Milton Finegold, Ergün Sahin
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Metabolites
Subjects:
telomeres
liver fibrosis
p53
fructose
triglyceride
Online Access:https://www.mdpi.com/2218-1989/11/6/394

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