Safety and Efficacy of Low-Dose Continuous Infusion of Landiolol, an Ultra-Short-Acting β-blocker, in Cardiac Surgery
Introduction: Landiolol hydrochloride is an ultra-short-acting β-blocker that is administered intravenously and has many advantages in cardiac surgery. This study was performed to examine the safety and efficacy of low-dose landiolol continuous infusion in cardiac surgery. Methods and Results: Ninet...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Arrhythmia |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1880427611800086 |
| _version_ | 1811263411487506432 |
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| author | Manabu Sato, MD Etsuro Suenaga, MD Hideyuki Fumoto, MD Hiromitsu Kawasaki, MD Shugo Koga, MD Fumie Maki, MD |
| author_facet | Manabu Sato, MD Etsuro Suenaga, MD Hideyuki Fumoto, MD Hiromitsu Kawasaki, MD Shugo Koga, MD Fumie Maki, MD |
| author_sort | Manabu Sato, MD |
| collection | DOAJ |
| description | Introduction: Landiolol hydrochloride is an ultra-short-acting β-blocker that is administered intravenously and has many advantages in cardiac surgery. This study was performed to examine the safety and efficacy of low-dose landiolol continuous infusion in cardiac surgery.
Methods and Results: Nineteen patients who underwent either aortic valve replacement or coronary artery bypass surgery received low-dose continuous infusion of landiolol (2.8 ± 0.75 μg/kg/min. from the time of skin incision until the second postoperative day. Nineteen patients who did not receive landiolol served as controls. Heart rate, arterial pressure, cardiac index, and stroke volume were measured and the occurrence of supraventricular tachyarrythmia was monitored for one week after surgery. Landiolol decreased the heart rate without causing hemodynamic deterioration. The incidence of supraventricular tachyarrythmia was 32% and 47% in the landiolol and control groups, respectively (P = 0.50).
Conclusions: Landiolol is effective for decreasing heart rate while maintaining other hemodynamic parameters. Our data did not show a clear prophylactic effect of landiolol on postoperative supraventricular tachyarrythmia. |
| first_indexed | 2024-04-12T19:43:38Z |
| format | Article |
| id | doaj.art-dc704dbbe7e74f93b48e1970c8bd8939 |
| institution | Directory Open Access Journal |
| issn | 1880-4276 |
| language | English |
| last_indexed | 2024-04-12T19:43:38Z |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Arrhythmia |
| spelling | doaj.art-dc704dbbe7e74f93b48e1970c8bd89392022-12-22T03:19:01ZengWileyJournal of Arrhythmia1880-42762011-01-01271576210.1016/S1880-4276(11)80008-6Safety and Efficacy of Low-Dose Continuous Infusion of Landiolol, an Ultra-Short-Acting β-blocker, in Cardiac SurgeryManabu Sato, MDEtsuro Suenaga, MDHideyuki Fumoto, MDHiromitsu Kawasaki, MDShugo Koga, MDFumie Maki, MDIntroduction: Landiolol hydrochloride is an ultra-short-acting β-blocker that is administered intravenously and has many advantages in cardiac surgery. This study was performed to examine the safety and efficacy of low-dose landiolol continuous infusion in cardiac surgery. Methods and Results: Nineteen patients who underwent either aortic valve replacement or coronary artery bypass surgery received low-dose continuous infusion of landiolol (2.8 ± 0.75 μg/kg/min. from the time of skin incision until the second postoperative day. Nineteen patients who did not receive landiolol served as controls. Heart rate, arterial pressure, cardiac index, and stroke volume were measured and the occurrence of supraventricular tachyarrythmia was monitored for one week after surgery. Landiolol decreased the heart rate without causing hemodynamic deterioration. The incidence of supraventricular tachyarrythmia was 32% and 47% in the landiolol and control groups, respectively (P = 0.50). Conclusions: Landiolol is effective for decreasing heart rate while maintaining other hemodynamic parameters. Our data did not show a clear prophylactic effect of landiolol on postoperative supraventricular tachyarrythmia.http://www.sciencedirect.com/science/article/pii/S1880427611800086Ultra-short-acting β-blockerLandiololHemodynamicsSupraventricular tachyarrythmiaCardiac surgery |
| spellingShingle | Manabu Sato, MD Etsuro Suenaga, MD Hideyuki Fumoto, MD Hiromitsu Kawasaki, MD Shugo Koga, MD Fumie Maki, MD Safety and Efficacy of Low-Dose Continuous Infusion of Landiolol, an Ultra-Short-Acting β-blocker, in Cardiac Surgery Journal of Arrhythmia Ultra-short-acting β-blocker Landiolol Hemodynamics Supraventricular tachyarrythmia Cardiac surgery |
| title | Safety and Efficacy of Low-Dose Continuous Infusion of Landiolol, an Ultra-Short-Acting β-blocker, in Cardiac Surgery |
| title_full | Safety and Efficacy of Low-Dose Continuous Infusion of Landiolol, an Ultra-Short-Acting β-blocker, in Cardiac Surgery |
| title_fullStr | Safety and Efficacy of Low-Dose Continuous Infusion of Landiolol, an Ultra-Short-Acting β-blocker, in Cardiac Surgery |
| title_full_unstemmed | Safety and Efficacy of Low-Dose Continuous Infusion of Landiolol, an Ultra-Short-Acting β-blocker, in Cardiac Surgery |
| title_short | Safety and Efficacy of Low-Dose Continuous Infusion of Landiolol, an Ultra-Short-Acting β-blocker, in Cardiac Surgery |
| title_sort | safety and efficacy of low dose continuous infusion of landiolol an ultra short acting β blocker in cardiac surgery |
| topic | Ultra-short-acting β-blocker Landiolol Hemodynamics Supraventricular tachyarrythmia Cardiac surgery |
| url | http://www.sciencedirect.com/science/article/pii/S1880427611800086 |
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