The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis
Psoriasis is a chronic inflammatory skin disease resulting from genetic, epigenetic, environmental, and lifestyle factors. To date, several immunopathogenic mechanisms of psoriasis have been elucidated, and, in the current model, the cross talk between autoreactive T cells and resident keratinocytes...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01549/full |
| _version_ | 1819133360295903232 |
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| author | Cristina Albanesi Stefania Madonna Paolo Gisondi Giampiero Girolomoni |
| author_facet | Cristina Albanesi Stefania Madonna Paolo Gisondi Giampiero Girolomoni |
| author_sort | Cristina Albanesi |
| collection | DOAJ |
| description | Psoriasis is a chronic inflammatory skin disease resulting from genetic, epigenetic, environmental, and lifestyle factors. To date, several immunopathogenic mechanisms of psoriasis have been elucidated, and, in the current model, the cross talk between autoreactive T cells and resident keratinocytes generates inflammatory and immune circuits responsible for the initiation, progression, and persistence of the disease. Several autoantigens derived from keratinocytes (i.e., LL37 cathelecidin/nucleic acid complexes, newly generated lipid antigens) have been identified, which may trigger initial activation of T cells, particularly IL-17-producing T cells, T helper (Th)1 and Th22 cells. Hence, lymphokines released in skin lesions are pivotal for keratinocyte activation and production of inflammatory molecules, which in turn lead to amplification of the local immune responses. Intrinsic genetic alterations of keratinocytes in the activation of signal transduction pathways dependent on T-cell-derived cytokines are also fundamental. The current review emphasizes the aberrant interplay of immune cells and skin-resident keratinocytes in establishing and sustaining inflammatory and immune responses in psoriasis. |
| first_indexed | 2024-12-22T09:46:03Z |
| format | Article |
| id | doaj.art-dc71b21f132a47eab223f3f860f7b6db |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T09:46:03Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-dc71b21f132a47eab223f3f860f7b6db2022-12-21T18:30:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-07-01910.3389/fimmu.2018.01549386664The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of PsoriasisCristina Albanesi0Stefania Madonna1Paolo Gisondi2Giampiero Girolomoni3Laboratory of Experimental Immunology, Istituto Dermopatico dell’Immacolata (IDI), IRCCS, Rome, ItalyLaboratory of Experimental Immunology, Istituto Dermopatico dell’Immacolata (IDI), IRCCS, Rome, ItalySection of Dermatology, Department of Medicine, University of Verona, Verona, ItalySection of Dermatology, Department of Medicine, University of Verona, Verona, ItalyPsoriasis is a chronic inflammatory skin disease resulting from genetic, epigenetic, environmental, and lifestyle factors. To date, several immunopathogenic mechanisms of psoriasis have been elucidated, and, in the current model, the cross talk between autoreactive T cells and resident keratinocytes generates inflammatory and immune circuits responsible for the initiation, progression, and persistence of the disease. Several autoantigens derived from keratinocytes (i.e., LL37 cathelecidin/nucleic acid complexes, newly generated lipid antigens) have been identified, which may trigger initial activation of T cells, particularly IL-17-producing T cells, T helper (Th)1 and Th22 cells. Hence, lymphokines released in skin lesions are pivotal for keratinocyte activation and production of inflammatory molecules, which in turn lead to amplification of the local immune responses. Intrinsic genetic alterations of keratinocytes in the activation of signal transduction pathways dependent on T-cell-derived cytokines are also fundamental. The current review emphasizes the aberrant interplay of immune cells and skin-resident keratinocytes in establishing and sustaining inflammatory and immune responses in psoriasis.https://www.frontiersin.org/article/10.3389/fimmu.2018.01549/fullpsoriasiskeratinocytesimmune cellsskin inflammationinnate immunityadaptive immunity |
| spellingShingle | Cristina Albanesi Stefania Madonna Paolo Gisondi Giampiero Girolomoni The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis Frontiers in Immunology psoriasis keratinocytes immune cells skin inflammation innate immunity adaptive immunity |
| title | The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis |
| title_full | The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis |
| title_fullStr | The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis |
| title_full_unstemmed | The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis |
| title_short | The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis |
| title_sort | interplay between keratinocytes and immune cells in the pathogenesis of psoriasis |
| topic | psoriasis keratinocytes immune cells skin inflammation innate immunity adaptive immunity |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01549/full |
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