18F-FDG-PET/CT for Localizing the Epileptogenic Focus in Patients with Different Types of Focal Cortical Dysplasia
Feng Wang,1,* Shu-Ting Hong,1,* Ying Zhang,2 Zhen Xing,3 Yuan-Xiang Lin1 1Neurosurgery Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Nuclear Medicine Department, the First Affiliated Hospital of Fujian Medical Uni...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-02-01
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| Series: | Neuropsychiatric Disease and Treatment |
| Subjects: | |
| Online Access: | https://www.dovepress.com/18f-fdg-petct-for-localizing-the-epileptogenic-focus-in-patients-with--peer-reviewed-fulltext-article-NDT |
| _version_ | 1797325402425786368 |
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| author | Wang F Hong ST Zhang Y Xing Z Lin YX |
| author_facet | Wang F Hong ST Zhang Y Xing Z Lin YX |
| author_sort | Wang F |
| collection | DOAJ |
| description | Feng Wang,1,* Shu-Ting Hong,1,* Ying Zhang,2 Zhen Xing,3 Yuan-Xiang Lin1 1Neurosurgery Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Nuclear Medicine Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 3Radiology Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuan-Xiang Lin, Neurosurgery Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China, Tel +8613906918894, Fax +86-591-83569369, Email lyx99070@163.comPurpose: To determine the diagnostic and localization value of 18F-fluorodeoxyglucose-positron emission tomography (PET)/computed tomography (CT) in patients with focal cortical dysplasia (FCD) who underwent epilepsy surgery.Methods: One hundred and eight patients with pathologically proven FCD who underwent surgery for refractory epilepsy were retrospectively analyzed. All patients underwent magnetic resonance imaging (MRI), 18F-FDG-PET/CT, and video electroencephalography. An MRI diagnosis of FCD was defined as MRI+. A PET/CT diagnosis of FCD was defined as PET/CT+.Results: MRI and PET/CT detected FCD in 20.37% and 93.52% of patients, respectively. The difference was significant. Twenty-one patients were MRI+/PET+, 80 were MRI-/PET+, six were MRI-/PET-, and one was MRI+/PET-. The MRI positivity rate was lowest in patients with FCD type IIIa (5.6%, P < 0.05). Prevalence of MRI-/PET+ was highest in patients with FCD type IIIa (88.89%, P < 0.05).Conclusion: PET/CT is superior to MRI in detecting FCD. FCD type IIIa was more likely than other types to show MRI-/PET+. This suggests that PET/CT has particular diagnostic value for FCD type IIIa patients with negative MRI findings.Keywords: focal cortical dysplasia, epilepsy, 18F-FDG-PET/CT, pathological types |
| first_indexed | 2024-03-08T06:08:58Z |
| format | Article |
| id | doaj.art-dc731f66f5e64db18d70b0967bcc1e96 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-03-08T06:08:58Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-dc731f66f5e64db18d70b0967bcc1e962024-02-04T17:43:33ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212024-02-01Volume 202112209023018F-FDG-PET/CT for Localizing the Epileptogenic Focus in Patients with Different Types of Focal Cortical DysplasiaWang FHong STZhang YXing ZLin YXFeng Wang,1,* Shu-Ting Hong,1,* Ying Zhang,2 Zhen Xing,3 Yuan-Xiang Lin1 1Neurosurgery Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Nuclear Medicine Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 3Radiology Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuan-Xiang Lin, Neurosurgery Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China, Tel +8613906918894, Fax +86-591-83569369, Email lyx99070@163.comPurpose: To determine the diagnostic and localization value of 18F-fluorodeoxyglucose-positron emission tomography (PET)/computed tomography (CT) in patients with focal cortical dysplasia (FCD) who underwent epilepsy surgery.Methods: One hundred and eight patients with pathologically proven FCD who underwent surgery for refractory epilepsy were retrospectively analyzed. All patients underwent magnetic resonance imaging (MRI), 18F-FDG-PET/CT, and video electroencephalography. An MRI diagnosis of FCD was defined as MRI+. A PET/CT diagnosis of FCD was defined as PET/CT+.Results: MRI and PET/CT detected FCD in 20.37% and 93.52% of patients, respectively. The difference was significant. Twenty-one patients were MRI+/PET+, 80 were MRI-/PET+, six were MRI-/PET-, and one was MRI+/PET-. The MRI positivity rate was lowest in patients with FCD type IIIa (5.6%, P < 0.05). Prevalence of MRI-/PET+ was highest in patients with FCD type IIIa (88.89%, P < 0.05).Conclusion: PET/CT is superior to MRI in detecting FCD. FCD type IIIa was more likely than other types to show MRI-/PET+. This suggests that PET/CT has particular diagnostic value for FCD type IIIa patients with negative MRI findings.Keywords: focal cortical dysplasia, epilepsy, 18F-FDG-PET/CT, pathological typeshttps://www.dovepress.com/18f-fdg-petct-for-localizing-the-epileptogenic-focus-in-patients-with--peer-reviewed-fulltext-article-NDTfocal cortical dysplasiaepilepsy18f-fdg-pet/ctpathological types |
| spellingShingle | Wang F Hong ST Zhang Y Xing Z Lin YX 18F-FDG-PET/CT for Localizing the Epileptogenic Focus in Patients with Different Types of Focal Cortical Dysplasia Neuropsychiatric Disease and Treatment focal cortical dysplasia epilepsy 18f-fdg-pet/ct pathological types |
| title | 18F-FDG-PET/CT for Localizing the Epileptogenic Focus in Patients with Different Types of Focal Cortical Dysplasia |
| title_full | 18F-FDG-PET/CT for Localizing the Epileptogenic Focus in Patients with Different Types of Focal Cortical Dysplasia |
| title_fullStr | 18F-FDG-PET/CT for Localizing the Epileptogenic Focus in Patients with Different Types of Focal Cortical Dysplasia |
| title_full_unstemmed | 18F-FDG-PET/CT for Localizing the Epileptogenic Focus in Patients with Different Types of Focal Cortical Dysplasia |
| title_short | 18F-FDG-PET/CT for Localizing the Epileptogenic Focus in Patients with Different Types of Focal Cortical Dysplasia |
| title_sort | 18f fdg pet ct for localizing the epileptogenic focus in patients with different types of focal cortical dysplasia |
| topic | focal cortical dysplasia epilepsy 18f-fdg-pet/ct pathological types |
| url | https://www.dovepress.com/18f-fdg-petct-for-localizing-the-epileptogenic-focus-in-patients-with--peer-reviewed-fulltext-article-NDT |
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