Role of Polymer Concentration on the Release Rates of Proteins from Single- and Double-Network Hydrogels
Controlled delivery of proteins has immense potential for the treatment of various human diseases, but effective strategies for their delivery are required before this potential can be fully realized. Recent research has identified hydrogels as a promising option for the controlled delivery of thera...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/23/16970 |
| _version_ | 1797400076595757056 |
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| author | Daryn Browne Francesca Briggs Prashanth Asuri |
| author_facet | Daryn Browne Francesca Briggs Prashanth Asuri |
| author_sort | Daryn Browne |
| collection | DOAJ |
| description | Controlled delivery of proteins has immense potential for the treatment of various human diseases, but effective strategies for their delivery are required before this potential can be fully realized. Recent research has identified hydrogels as a promising option for the controlled delivery of therapeutic proteins, owing to their ability to respond to diverse chemical and biological stimuli, as well as their customizable properties that allow for desired delivery rates. This study utilized alginate and chitosan as model polymers to investigate the effects of hydrogel properties on protein release rates. The results demonstrated that polymer properties, concentration, and crosslinking density, as well as their responses to pH, can be tailored to regulate protein release rates. The study also revealed that hydrogels may be combined to create double-network hydrogels to provide an additional metric to control protein release rates. Furthermore, the hydrogel scaffolds were also found to preserve the long-term function and structure of encapsulated proteins before their release from the hydrogels. In conclusion, this research demonstrates the significance of integrating porosity and response to stimuli as orthogonal control parameters when designing hydrogel-based scaffolds for therapeutic protein release. |
| first_indexed | 2024-03-09T01:50:18Z |
| format | Article |
| id | doaj.art-dc745039c533409e825fff3e75665db4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T01:50:18Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dc745039c533409e825fff3e75665db42023-12-08T15:17:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124231697010.3390/ijms242316970Role of Polymer Concentration on the Release Rates of Proteins from Single- and Double-Network HydrogelsDaryn Browne0Francesca Briggs1Prashanth Asuri2Department of Bioengineering, Santa Clara University, Santa Clara, CA 95053, USADepartment of Bioengineering, Santa Clara University, Santa Clara, CA 95053, USADepartment of Bioengineering, Santa Clara University, Santa Clara, CA 95053, USAControlled delivery of proteins has immense potential for the treatment of various human diseases, but effective strategies for their delivery are required before this potential can be fully realized. Recent research has identified hydrogels as a promising option for the controlled delivery of therapeutic proteins, owing to their ability to respond to diverse chemical and biological stimuli, as well as their customizable properties that allow for desired delivery rates. This study utilized alginate and chitosan as model polymers to investigate the effects of hydrogel properties on protein release rates. The results demonstrated that polymer properties, concentration, and crosslinking density, as well as their responses to pH, can be tailored to regulate protein release rates. The study also revealed that hydrogels may be combined to create double-network hydrogels to provide an additional metric to control protein release rates. Furthermore, the hydrogel scaffolds were also found to preserve the long-term function and structure of encapsulated proteins before their release from the hydrogels. In conclusion, this research demonstrates the significance of integrating porosity and response to stimuli as orthogonal control parameters when designing hydrogel-based scaffolds for therapeutic protein release.https://www.mdpi.com/1422-0067/24/23/16970protein deliverycontrolled releasepolymer concentrationhydrogel crosslinking densitydouble-network hydrogels |
| spellingShingle | Daryn Browne Francesca Briggs Prashanth Asuri Role of Polymer Concentration on the Release Rates of Proteins from Single- and Double-Network Hydrogels International Journal of Molecular Sciences protein delivery controlled release polymer concentration hydrogel crosslinking density double-network hydrogels |
| title | Role of Polymer Concentration on the Release Rates of Proteins from Single- and Double-Network Hydrogels |
| title_full | Role of Polymer Concentration on the Release Rates of Proteins from Single- and Double-Network Hydrogels |
| title_fullStr | Role of Polymer Concentration on the Release Rates of Proteins from Single- and Double-Network Hydrogels |
| title_full_unstemmed | Role of Polymer Concentration on the Release Rates of Proteins from Single- and Double-Network Hydrogels |
| title_short | Role of Polymer Concentration on the Release Rates of Proteins from Single- and Double-Network Hydrogels |
| title_sort | role of polymer concentration on the release rates of proteins from single and double network hydrogels |
| topic | protein delivery controlled release polymer concentration hydrogel crosslinking density double-network hydrogels |
| url | https://www.mdpi.com/1422-0067/24/23/16970 |
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