Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability

Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability

Abstract Background Transcription factor c-Myc plays a critical role in various physiological and pathological events. c-Myc gene rearrangement is closely associated with multiple myeloma (MM) progression and drug resistance. Thereby, targeting c-Myc is expected to be a useful therapeutic strategy f...

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Bibliographic Details
Main Authors: Ruosi Yao, Menghui Zhang, Jian Zhou, Linlin Liu, Yan Zhang, Jian Gao, Kailin Xu
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Cell Communication and Signaling
Subjects:
c-Myc inhibitor
Multiple myeloma
DNA damage
Drug resistance
Apoptosis
Online Access:https://doi.org/10.1186/s12964-022-00868-6

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