Preliminary Study of Iron Concentration in the Human Placenta in Twin Pregnancies
Background: Pregnancy significantly increases the demand for iron (Fe) in the female body to facilitate maternal blood volume expansion, placental development, and fetal growth. As Fe flux in pregnancy is significantly influenced by the placenta, the aim of this study was to determine the dependenci...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/5/749 |
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| author | Konrad Grzeszczak Patrycja Kapczuk Patrycja Kupnicka Maciej Mularczyk Sebastian Kwiatkowski Dariusz Chlubek Danuta Kosik-Bogacka |
| author_facet | Konrad Grzeszczak Patrycja Kapczuk Patrycja Kupnicka Maciej Mularczyk Sebastian Kwiatkowski Dariusz Chlubek Danuta Kosik-Bogacka |
| author_sort | Konrad Grzeszczak |
| collection | DOAJ |
| description | Background: Pregnancy significantly increases the demand for iron (Fe) in the female body to facilitate maternal blood volume expansion, placental development, and fetal growth. As Fe flux in pregnancy is significantly influenced by the placenta, the aim of this study was to determine the dependencies between the Fe concentration in the placenta, the infant’s morphometric parameters and the woman’s morphological blood parameters in the last trimester. Methods: The study was conducted on 33 women with multiple (dichorionic–diamniotic) pregnancies from whom the placentas were drawn, and their 66 infants, including pairs of monozygotic (n = 23) and mixed-sex twins (n = 10). Fe concentrations were determined based on inductively coupled plasma atomic emission spectroscopy (ICP-OES) using ICAP 7400 Duo, Thermo Scientific. Results: The results of the analysis showed that lower placental Fe concentrations were associated with deteriorated morphometric parameters of infants, including weight and head circumference. Although we found no statistically significant dependencies between Fe concentration in the placenta and the women’s morphological blood parameters, higher Fe concentration in the placenta of mothers supplemented with Fe correlated with better morphometric parameters in infants compared to those whose mothers received no Fe supplementation. Conclusions: The research adds additional knowledge for placental iron-related processes during multiple pregnancies. However, many limitations of the study do not allow detailed conclusions to be assessed, and statistical data should be assessed conservatively. |
| first_indexed | 2024-03-11T03:55:11Z |
| format | Article |
| id | doaj.art-dc7471054e004f2c90bcb45451b3e36c |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T03:55:11Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-dc7471054e004f2c90bcb45451b3e36c2023-11-18T00:38:37ZengMDPI AGBiomolecules2218-273X2023-04-0113574910.3390/biom13050749Preliminary Study of Iron Concentration in the Human Placenta in Twin PregnanciesKonrad Grzeszczak0Patrycja Kapczuk1Patrycja Kupnicka2Maciej Mularczyk3Sebastian Kwiatkowski4Dariusz Chlubek5Danuta Kosik-Bogacka6Department of Biology and Medical Parasitology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandChair and Department of Human and Clinical Anatomy, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandIndependent Laboratory of Pharmaceutical Botany, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandBackground: Pregnancy significantly increases the demand for iron (Fe) in the female body to facilitate maternal blood volume expansion, placental development, and fetal growth. As Fe flux in pregnancy is significantly influenced by the placenta, the aim of this study was to determine the dependencies between the Fe concentration in the placenta, the infant’s morphometric parameters and the woman’s morphological blood parameters in the last trimester. Methods: The study was conducted on 33 women with multiple (dichorionic–diamniotic) pregnancies from whom the placentas were drawn, and their 66 infants, including pairs of monozygotic (n = 23) and mixed-sex twins (n = 10). Fe concentrations were determined based on inductively coupled plasma atomic emission spectroscopy (ICP-OES) using ICAP 7400 Duo, Thermo Scientific. Results: The results of the analysis showed that lower placental Fe concentrations were associated with deteriorated morphometric parameters of infants, including weight and head circumference. Although we found no statistically significant dependencies between Fe concentration in the placenta and the women’s morphological blood parameters, higher Fe concentration in the placenta of mothers supplemented with Fe correlated with better morphometric parameters in infants compared to those whose mothers received no Fe supplementation. Conclusions: The research adds additional knowledge for placental iron-related processes during multiple pregnancies. However, many limitations of the study do not allow detailed conclusions to be assessed, and statistical data should be assessed conservatively.https://www.mdpi.com/2218-273X/13/5/749ironmultiple pregnancyhuman placenta |
| spellingShingle | Konrad Grzeszczak Patrycja Kapczuk Patrycja Kupnicka Maciej Mularczyk Sebastian Kwiatkowski Dariusz Chlubek Danuta Kosik-Bogacka Preliminary Study of Iron Concentration in the Human Placenta in Twin Pregnancies Biomolecules iron multiple pregnancy human placenta |
| title | Preliminary Study of Iron Concentration in the Human Placenta in Twin Pregnancies |
| title_full | Preliminary Study of Iron Concentration in the Human Placenta in Twin Pregnancies |
| title_fullStr | Preliminary Study of Iron Concentration in the Human Placenta in Twin Pregnancies |
| title_full_unstemmed | Preliminary Study of Iron Concentration in the Human Placenta in Twin Pregnancies |
| title_short | Preliminary Study of Iron Concentration in the Human Placenta in Twin Pregnancies |
| title_sort | preliminary study of iron concentration in the human placenta in twin pregnancies |
| topic | iron multiple pregnancy human placenta |
| url | https://www.mdpi.com/2218-273X/13/5/749 |
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