Effect of acupuncture for non-motor symptoms in patients with Parkinson’s disease: A systematic review and meta-analysis
BackgroundAlthough non-motor symptoms of Parkinson’s disease (PD) are serious, effective treatments are still lacking. Acupuncture may have clinical benefits for non-motor symptoms of PD patients, but high-quality evidence supporting this possibility is still limited. Hence, we conducted this meta-a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.995850/full |
| _version_ | 1811196233537028096 |
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| author | Qinglian Li Chunxiao Wu Chunxiao Wu Xiaoling Wang Zhen Li Xiaoqian Hao Lijun Zhao Mengzhu Li Meiling Zhu |
| author_facet | Qinglian Li Chunxiao Wu Chunxiao Wu Xiaoling Wang Zhen Li Xiaoqian Hao Lijun Zhao Mengzhu Li Meiling Zhu |
| author_sort | Qinglian Li |
| collection | DOAJ |
| description | BackgroundAlthough non-motor symptoms of Parkinson’s disease (PD) are serious, effective treatments are still lacking. Acupuncture may have clinical benefits for non-motor symptoms of PD patients, but high-quality evidence supporting this possibility is still limited. Hence, we conducted this meta-analysis to evaluate the effect of acupuncture treatment on non-motor symptoms in patients with PD.MethodsRandomized controlled trials (RCTs) of acupuncture treatment for PD were retrieved from the following electronic databases: Medline (OVID), Embase (OVID), Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese BioMedical Literature Database, Chonqing VIP (CQVIP), and Wangfang database. Studies evaluating non-motor symptoms of PD were retrieved. Methodological quality was assessed using the Cochrane Handbook for Systematic Reviews of Interventions.ResultsA total of 27 RCTs were included, among which 8 outcomes related to non-motor symptoms were evaluated. The results showed that acupuncture combined with medication had benefits for PD-related insomnia relative to medication alone or sham acupuncture [standardized mean difference (SMD) = 0.517; 95% confidence interval (CI) = 0.242–0.793; p = 0.000], and acupuncture treatment had benefits at 8 weeks (SMD = 0.519; 95% CI = 0.181–0.857; p = 0.003). Regarding depression, acupuncture treatment was more effective (SMD = −0.353; 95% CI = −0.669 to −0.037; p = 0.029) within 2 months (SMD = −0.671; 95% CI = −1.332 to −0.011; p = 0.046). Regarding cognition, quality of life, and Unified Parkinson’s Disease Rating Scale (UPDRS) I and II scores, acupuncture treatment was effective [SMD = 0.878, 95% CI = 0.046–1.711, p = 0.039; SMD = −0.690, 95% CI = −1.226 to −0.155, p = 0.011; weighted mean difference (WMD) = −1.536, 95% CI = −2.201 to −0.871, p = 0.000; WMD = −2.071, 95% CI = −3.792 to −0.351, p = 0.018; respectively]. A significant difference was not found in terms of PD-related constipation. Only one study evaluated PD-related fatigue.ConclusionThe results of the analysis suggested that acupuncture treatment could ameliorate the symptoms of depression, quality of life, cognition, total mentation, behavior and mood, and activities of daily living in PD patients. Nevertheless, more prospective, well-designed RCTs with larger sample sizes are required to confirm our findings. |
| first_indexed | 2024-04-12T00:55:11Z |
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| id | doaj.art-dc7473f5330e4aad90369a6c532fba26 |
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| language | English |
| last_indexed | 2024-04-12T00:55:11Z |
| publishDate | 2022-10-01 |
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| spelling | doaj.art-dc7473f5330e4aad90369a6c532fba262022-12-22T03:54:38ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-10-011410.3389/fnagi.2022.995850995850Effect of acupuncture for non-motor symptoms in patients with Parkinson’s disease: A systematic review and meta-analysisQinglian Li0Chunxiao Wu1Chunxiao Wu2Xiaoling Wang3Zhen Li4Xiaoqian Hao5Lijun Zhao6Mengzhu Li7Meiling Zhu8Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, ChinaShenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, ChinaThe Research Center of Basic Integrative Medicine, Guangzhou University of Chinese Medicine, Guangzhou, ChinaShenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, ChinaShenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, ChinaShenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, ChinaShenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, ChinaShenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, ChinaShenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, ChinaBackgroundAlthough non-motor symptoms of Parkinson’s disease (PD) are serious, effective treatments are still lacking. Acupuncture may have clinical benefits for non-motor symptoms of PD patients, but high-quality evidence supporting this possibility is still limited. Hence, we conducted this meta-analysis to evaluate the effect of acupuncture treatment on non-motor symptoms in patients with PD.MethodsRandomized controlled trials (RCTs) of acupuncture treatment for PD were retrieved from the following electronic databases: Medline (OVID), Embase (OVID), Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese BioMedical Literature Database, Chonqing VIP (CQVIP), and Wangfang database. Studies evaluating non-motor symptoms of PD were retrieved. Methodological quality was assessed using the Cochrane Handbook for Systematic Reviews of Interventions.ResultsA total of 27 RCTs were included, among which 8 outcomes related to non-motor symptoms were evaluated. The results showed that acupuncture combined with medication had benefits for PD-related insomnia relative to medication alone or sham acupuncture [standardized mean difference (SMD) = 0.517; 95% confidence interval (CI) = 0.242–0.793; p = 0.000], and acupuncture treatment had benefits at 8 weeks (SMD = 0.519; 95% CI = 0.181–0.857; p = 0.003). Regarding depression, acupuncture treatment was more effective (SMD = −0.353; 95% CI = −0.669 to −0.037; p = 0.029) within 2 months (SMD = −0.671; 95% CI = −1.332 to −0.011; p = 0.046). Regarding cognition, quality of life, and Unified Parkinson’s Disease Rating Scale (UPDRS) I and II scores, acupuncture treatment was effective [SMD = 0.878, 95% CI = 0.046–1.711, p = 0.039; SMD = −0.690, 95% CI = −1.226 to −0.155, p = 0.011; weighted mean difference (WMD) = −1.536, 95% CI = −2.201 to −0.871, p = 0.000; WMD = −2.071, 95% CI = −3.792 to −0.351, p = 0.018; respectively]. A significant difference was not found in terms of PD-related constipation. Only one study evaluated PD-related fatigue.ConclusionThe results of the analysis suggested that acupuncture treatment could ameliorate the symptoms of depression, quality of life, cognition, total mentation, behavior and mood, and activities of daily living in PD patients. Nevertheless, more prospective, well-designed RCTs with larger sample sizes are required to confirm our findings.https://www.frontiersin.org/articles/10.3389/fnagi.2022.995850/fullParkinson’s diseasenon-motor symptomsacupuncturemeta-analysisrandomized controlled trial |
| spellingShingle | Qinglian Li Chunxiao Wu Chunxiao Wu Xiaoling Wang Zhen Li Xiaoqian Hao Lijun Zhao Mengzhu Li Meiling Zhu Effect of acupuncture for non-motor symptoms in patients with Parkinson’s disease: A systematic review and meta-analysis Frontiers in Aging Neuroscience Parkinson’s disease non-motor symptoms acupuncture meta-analysis randomized controlled trial |
| title | Effect of acupuncture for non-motor symptoms in patients with Parkinson’s disease: A systematic review and meta-analysis |
| title_full | Effect of acupuncture for non-motor symptoms in patients with Parkinson’s disease: A systematic review and meta-analysis |
| title_fullStr | Effect of acupuncture for non-motor symptoms in patients with Parkinson’s disease: A systematic review and meta-analysis |
| title_full_unstemmed | Effect of acupuncture for non-motor symptoms in patients with Parkinson’s disease: A systematic review and meta-analysis |
| title_short | Effect of acupuncture for non-motor symptoms in patients with Parkinson’s disease: A systematic review and meta-analysis |
| title_sort | effect of acupuncture for non motor symptoms in patients with parkinson s disease a systematic review and meta analysis |
| topic | Parkinson’s disease non-motor symptoms acupuncture meta-analysis randomized controlled trial |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.995850/full |
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