Applying Patient and Public Involvement in preclinical research: A co‐created scoping review
Abstract Background Patient and Public Involvement (PPI) in research aims to improve the quality, relevance and appropriateness of research. PPI has an established role in clinical research where there is evidence of benefit, and where policymakers and funders place continued emphasis on its inclusi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-12-01
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| Series: | Health Expectations |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/hex.13615 |
| _version_ | 1798016154385514496 |
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| author | Pádraig Carroll Adrian Dervan Anthony Maher Ciarán McCarthy Ian Woods Rachel Kavanagh Mr Cliff Beirne Geoff Harte Dónal O'Flynn Cian O'Connor Tara McGuire Liam M. Leahy Javier Gutierrez Gonzalez Martyna Stasiewicz Jack Maughan Pedro Jose Gouveia Paul J. Murphy John Quinlan Sarah Casey Alice Holton Éimear Smith Frank Moriarty Fergal J. O'Brien Michelle Flood |
| author_facet | Pádraig Carroll Adrian Dervan Anthony Maher Ciarán McCarthy Ian Woods Rachel Kavanagh Mr Cliff Beirne Geoff Harte Dónal O'Flynn Cian O'Connor Tara McGuire Liam M. Leahy Javier Gutierrez Gonzalez Martyna Stasiewicz Jack Maughan Pedro Jose Gouveia Paul J. Murphy John Quinlan Sarah Casey Alice Holton Éimear Smith Frank Moriarty Fergal J. O'Brien Michelle Flood |
| author_sort | Pádraig Carroll |
| collection | DOAJ |
| description | Abstract Background Patient and Public Involvement (PPI) in research aims to improve the quality, relevance and appropriateness of research. PPI has an established role in clinical research where there is evidence of benefit, and where policymakers and funders place continued emphasis on its inclusion. However, for preclinical research, PPI has not yet achieved the same level of integration. As more researchers, including our team, aim to include PPI in preclinical research, the development of an evidence‐based approach is important. Therefore, this scoping review aimed to identify and map studies where PPI has been used in preclinical research and develop principles that can be applied in other projects. Methods A scoping review was conducted to search the literature in Medline (PubMed), EMBASE, CINAHL, PsycInfo and Web of Science Core Collection to identify applied examples of preclinical PPI. Two independent reviewers conducted study selection and data extraction separately. Data were extracted relating to PPI in terms of (i) rationale and aims, (ii) approach used, (iii) benefits and challenges, (iv) impact and evaluation and (v) learning opportunities for preclinical PPI. Findings were reviewed collaboratively by PPI contributors and the research team to identify principles that could be applied to other projects. Results Nine studies were included in the final review with the majority of included studies reporting PPI to improve the relevance of their research, using approaches such as PPI advisory panels and workshops. Researchers report several benefits and challenges, although evidence of formal evaluation is limited. Conclusion Although currently there are few examples of preclinical research studies reporting empirical PPI activity, their findings may support those aiming to use PPI in preclinical research. Through collaborative analysis of the scoping review findings, several principles were developed that may be useful for other preclinical researchers. Patient or Public Contribution This study was conducted as part of a broader project aiming to develop an evidence base for preclinical PPI that draws on a 5‐year preclinical research programme focused on the development of advanced biomaterials for spinal cord repair as a case study. A PPI Advisory Panel comprising seriously injured rugby players, clinicians, preclinical researchers and PPI facilitators collaborated as co‐authors on the conceptualization, execution and writing of this review, including refining the findings into the set of principles reported here. |
| first_indexed | 2024-04-11T15:46:14Z |
| format | Article |
| id | doaj.art-dc74864d21f8431695e854b168834097 |
| institution | Directory Open Access Journal |
| issn | 1369-6513 1369-7625 |
| language | English |
| last_indexed | 2024-04-11T15:46:14Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Expectations |
| spelling | doaj.art-dc74864d21f8431695e854b1688340972022-12-22T04:15:31ZengWileyHealth Expectations1369-65131369-76252022-12-012562680269910.1111/hex.13615Applying Patient and Public Involvement in preclinical research: A co‐created scoping reviewPádraig Carroll0Adrian Dervan1Anthony Maher2Ciarán McCarthy3Ian Woods4Rachel Kavanagh5Mr Cliff Beirne6Geoff Harte7Dónal O'Flynn8Cian O'Connor9Tara McGuire10Liam M. Leahy11Javier Gutierrez Gonzalez12Martyna Stasiewicz13Jack Maughan14Pedro Jose Gouveia15Paul J. Murphy16John Quinlan17Sarah Casey18Alice Holton19Éimear Smith20Frank Moriarty21Fergal J. O'Brien22Michelle Flood23School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health Sciences Dublin IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine RCSI University of Medicine and Health Sciences Dublin IrelandSchool of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health Sciences Dublin Irelandc/o Irish Rugby Football Union (IRFU) Charitable Trust Dublin IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine RCSI University of Medicine and Health Sciences Dublin IrelandScience Foundation Ireland (SFI) Advanced Materials and BioEngineering Research (AMBER) Centre Trinity College Dublin (TCD) and RCSI University of Medicine and Health Sciences Dublin IrelandFaculty of Sports and Exercise Medicines RCSI University of Medicine and Health Sciences & Royal College of Physicians in Ireland Dublin Irelandc/o Irish Rugby Football Union (IRFU) Charitable Trust Dublin Irelandc/o Irish Rugby Football Union (IRFU) Charitable Trust Dublin IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine RCSI University of Medicine and Health Sciences Dublin IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine RCSI University of Medicine and Health Sciences Dublin IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine RCSI University of Medicine and Health Sciences Dublin IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine RCSI University of Medicine and Health Sciences Dublin IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine RCSI University of Medicine and Health Sciences Dublin IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine RCSI University of Medicine and Health Sciences Dublin IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine RCSI University of Medicine and Health Sciences Dublin IrelandRCSI Library RCSI University of Medicine and Health Sciences Dublin IrelandTallaght University Hospital Dublin IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine RCSI University of Medicine and Health Sciences Dublin IrelandSchool of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health Sciences Dublin IrelandNational Rehabilitation Hospital Dún Laoghaire IrelandSchool of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health Sciences Dublin IrelandTissue Engineering Research Group (TERG), Department of Anatomy and Regenerative Medicine RCSI University of Medicine and Health Sciences Dublin IrelandSchool of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health Sciences Dublin IrelandAbstract Background Patient and Public Involvement (PPI) in research aims to improve the quality, relevance and appropriateness of research. PPI has an established role in clinical research where there is evidence of benefit, and where policymakers and funders place continued emphasis on its inclusion. However, for preclinical research, PPI has not yet achieved the same level of integration. As more researchers, including our team, aim to include PPI in preclinical research, the development of an evidence‐based approach is important. Therefore, this scoping review aimed to identify and map studies where PPI has been used in preclinical research and develop principles that can be applied in other projects. Methods A scoping review was conducted to search the literature in Medline (PubMed), EMBASE, CINAHL, PsycInfo and Web of Science Core Collection to identify applied examples of preclinical PPI. Two independent reviewers conducted study selection and data extraction separately. Data were extracted relating to PPI in terms of (i) rationale and aims, (ii) approach used, (iii) benefits and challenges, (iv) impact and evaluation and (v) learning opportunities for preclinical PPI. Findings were reviewed collaboratively by PPI contributors and the research team to identify principles that could be applied to other projects. Results Nine studies were included in the final review with the majority of included studies reporting PPI to improve the relevance of their research, using approaches such as PPI advisory panels and workshops. Researchers report several benefits and challenges, although evidence of formal evaluation is limited. Conclusion Although currently there are few examples of preclinical research studies reporting empirical PPI activity, their findings may support those aiming to use PPI in preclinical research. Through collaborative analysis of the scoping review findings, several principles were developed that may be useful for other preclinical researchers. Patient or Public Contribution This study was conducted as part of a broader project aiming to develop an evidence base for preclinical PPI that draws on a 5‐year preclinical research programme focused on the development of advanced biomaterials for spinal cord repair as a case study. A PPI Advisory Panel comprising seriously injured rugby players, clinicians, preclinical researchers and PPI facilitators collaborated as co‐authors on the conceptualization, execution and writing of this review, including refining the findings into the set of principles reported here.https://doi.org/10.1111/hex.13615consumer involvementpatient and public engagementPatient and Public Involvementpublic involvement in researchservice user |
| spellingShingle | Pádraig Carroll Adrian Dervan Anthony Maher Ciarán McCarthy Ian Woods Rachel Kavanagh Mr Cliff Beirne Geoff Harte Dónal O'Flynn Cian O'Connor Tara McGuire Liam M. Leahy Javier Gutierrez Gonzalez Martyna Stasiewicz Jack Maughan Pedro Jose Gouveia Paul J. Murphy John Quinlan Sarah Casey Alice Holton Éimear Smith Frank Moriarty Fergal J. O'Brien Michelle Flood Applying Patient and Public Involvement in preclinical research: A co‐created scoping review Health Expectations consumer involvement patient and public engagement Patient and Public Involvement public involvement in research service user |
| title | Applying Patient and Public Involvement in preclinical research: A co‐created scoping review |
| title_full | Applying Patient and Public Involvement in preclinical research: A co‐created scoping review |
| title_fullStr | Applying Patient and Public Involvement in preclinical research: A co‐created scoping review |
| title_full_unstemmed | Applying Patient and Public Involvement in preclinical research: A co‐created scoping review |
| title_short | Applying Patient and Public Involvement in preclinical research: A co‐created scoping review |
| title_sort | applying patient and public involvement in preclinical research a co created scoping review |
| topic | consumer involvement patient and public engagement Patient and Public Involvement public involvement in research service user |
| url | https://doi.org/10.1111/hex.13615 |
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