Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk

Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk

Alpha-synuclein accumulation in dopaminergic neurons is one of the primary features of Parkinson’s disease (PD). Despite its toxic properties during PD, alpha-synuclein has some important physiological functions. Although the activity of the protein has been extensively studied in neurons, the prote...

Descripció completa

Dades bibliogràfiques
Autors principals:	Alix Booms, Gerhard A. Coetzee
Format:	Article
Idioma:	English
Publicat:	Frontiers Media S.A. 2021-10-01
Col·lecció:	Frontiers in Cellular Neuroscience
Matèries:	SNCA alpha-synuclein microglia hematopoietic progenitors differentiation immune response
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fncel.2021.759571/full

Ítems similars

Genetic Elements at the Alpha-Synuclein Locus
per: Jordan Prahl, et al.
Publicat: (2022-07-01)

Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation
per: Katharina Pieger, et al.
Publicat: (2022-08-01)

Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes
per: Yihang Han, et al.
Publicat: (2022-06-01)

Intracellular Alpha-Synuclein and Immune Cell Function
per: Veselin Grozdanov, et al.
Publicat: (2020-10-01)

Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression
per: Sara J. Fagen, et al.
Publicat: (2023-08-01)

Bioinformatic network analysis on the molecular interactions between Parkinson’s disease, alpha-synuclein, and infertility condition
per: Velu Krishnan, et al.
Publicat: (2023-09-01)

Targeting α-Synuclein in Parkinson's Disease by Induced Pluripotent Stem Cell Models
per: Angeliki Spathopoulou, et al.
Publicat: (2022-01-01)

Temporal Evolution of Inflammation and Neurodegeneration With Alpha-Synuclein Propagation in Parkinson's Disease Mouse Model
per: Thuy Thi Lai, et al.
Publicat: (2021-10-01)

Subthalamic deep brain stimulation in Parkinson's disease with SNCA mutations: Based on the follow‐up to 10 years
per: Jinyoung Youn, et al.
Publicat: (2022-02-01)

Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease
per: Desiree A. Piper, et al.
Publicat: (2018-04-01)

Alpha-synuclein dynamics bridge Type-I Interferon response and SARS-CoV-2 replication in peripheral cells
per: Fiona Limanaqi, et al.
Publicat: (2024-01-01)

DNA methylation in Parkinson disease
per: Elena V. Yakovenko, et al.
Publicat: (2020-12-01)

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease
per: Sonia George, et al.
Publicat: (2019-08-01)

Alpha-synuclein as a biomarker of Parkinson’s disease
per: S. N. Pchelina
Publicat: (2017-02-01)

Transcriptome Analysis in a Mouse Model of Premature Aging of Dentate Gyrus: Rescue of Alpha-Synuclein Deficit by Virus-Driven Expression or by Running Restores the Defective Neurogenesis
per: Laura Micheli, et al.
Publicat: (2021-08-01)

Extracellular Alpha-Synuclein: Mechanisms for Glial Cell Internalization and Activation
per: Cecilia Chavarría, et al.
Publicat: (2022-04-01)

The Peripheral Inflammatory Response to Alpha-Synuclein and Endotoxin in Parkinson's Disease
per: Alice J. White, et al.
Publicat: (2018-11-01)

Pyrroloquinoline quinone influences intracellular alpha-synuclein aggregates
per: Elizabeth Mountford, et al.
Publicat: (2023-01-01)

RGS10 mitigates high glucose-induced microglial inflammation via the reactive oxidative stress pathway and enhances synuclein clearance in microglia
per: Jaegwon Chung, et al.
Publicat: (2024-05-01)

Alpha-Synuclein Aggregation in Parkinson's Disease
per: E. Srinivasan, et al.
Publicat: (2021-10-01)

The Role of Microglia and Astrocytes in the Pathomechanism of Neuroinflammation in Parkinson’s Disease—Focus on Alpha-Synuclein
per: Oliwia Harackiewicz, et al.
Publicat: (2024-11-01)

Variants in SNCA Gene Are Associated with Parkinson’s Disease Risk and Cognitive Symptoms in a Brazilian Sample
per: Clarissa L.C Campêlo, et al.
Publicat: (2017-06-01)

Emerging role of microglia in inter-cellular transmission of α-synuclein in Parkinson’s disease
per: Xiangbo Zhang, et al.
Publicat: (2024-10-01)

Passive Immunization in Alpha-Synuclein Preclinical Animal Models
per: Jonas Folke, et al.
Publicat: (2022-01-01)

Interactions of alpha-synuclein with membranes in Parkinson's disease: Mechanisms and therapeutic strategies
per: Baoyi Li, et al.
Publicat: (2024-10-01)

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation
per: Couch Yvonne, et al.
Publicat: (2011-11-01)

Age-dependent progression from clearance to vulnerability in the early response of periventricular microglia to α-synuclein toxic species
per: Mª Salomé Sirerol-Piquer, et al.
Publicat: (2025-03-01)

A population scale analysis of rare SNCA variation in the UK Biobank
per: Cornelis Blauwendraat, et al.
Publicat: (2021-01-01)

Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol
per: Sarah Threlfell, et al.
Publicat: (2021-04-01)

The Small Molecule Alpha-Synuclein Aggregator, FN075, Enhances Alpha-Synuclein Pathology in Subclinical AAV Rat Models
per: Rachel Kelly, et al.
Publicat: (2021-11-01)

Extracellular alpha-synuclein: Sensors, receptors, and responses
per: Renato Domingues, et al.
Publicat: (2022-06-01)

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration
per: Ashley S. Harms, et al.
Publicat: (2017-11-01)

Editorial: Biomarkers and Pathogenesis of Alpha-Synuclein in Parkinson's Disease
per: Puyu Li, et al.
Publicat: (2021-10-01)

Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson’s disease: a genetic association study
per: Kari Anne Bjørnarå, et al.
Publicat: (2018-02-01)

Neuronal activity triggers secretory autophagy to mediate the extracellular release of SNCA/α-synuclein
per: Yoshitsugu Nakamura, et al.
Publicat: (2024-12-01)

Rationale for Therapeutic Silencing of Alpha-Synuclein in Parkinson’s Disease
per: Demetrius M. Maraganore
Publicat: (2011-05-01)

Interaction between Neuromelanin and Alpha-Synuclein in Parkinson’s Disease
per: Shengli Xu, et al.
Publicat: (2015-06-01)

Parkinson Hastalığı ve İlişkili Olduğu Genler
per: Yener Kurman
Publicat: (2018-01-01)

SNCA rs3910105 Is Associated With Development of Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease
per: Nan-nan Yang, et al.
Publicat: (2022-03-01)

Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions
per: Anna C. Stoll, et al.
Publicat: (2024-02-01)