Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report
Summary: We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation, not vaccinated for SARS-COV-2, hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit (ICU). The hospitalization was complica...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Infectious Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772431X23000096 |
| _version_ | 1797345879983652864 |
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| author | Rosa Anna Passerotto Francesco Lamanna Damiano Farinacci Alex Dusina Simona Di Giambenedetto Arturo Ciccullo Alberto Borghetti |
| author_facet | Rosa Anna Passerotto Francesco Lamanna Damiano Farinacci Alex Dusina Simona Di Giambenedetto Arturo Ciccullo Alberto Borghetti |
| author_sort | Rosa Anna Passerotto |
| collection | DOAJ |
| description | Summary: We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation, not vaccinated for SARS-COV-2, hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit (ICU). The hospitalization was complicated by bacteraemic ventilator-associated pneumonia (VAP) caused by multidrug-resistant Acinetobacter baumannii (MDR-AB) isolated on pleural fluid culture, treated with colistin and cefiderocol for about 3 weeks. The molecular research of MDR-AB on transtracheal aspirate was negative following this therapy.The aim is to show the safety, efficacy and tolerability of colistin-based combination therapy with cefiderocol for Acinetobacter baumannii infection in HIV-infected patient. |
| first_indexed | 2024-03-08T11:25:06Z |
| format | Article |
| id | doaj.art-dc783032dccc435ea2578fe06f407ce7 |
| institution | Directory Open Access Journal |
| issn | 2772-431X |
| language | English |
| last_indexed | 2024-03-08T11:25:06Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Infectious Medicine |
| spelling | doaj.art-dc783032dccc435ea2578fe06f407ce72024-01-26T05:36:24ZengElsevierInfectious Medicine2772-431X2023-06-0122143147Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case reportRosa Anna Passerotto0Francesco Lamanna1Damiano Farinacci2Alex Dusina3Simona Di Giambenedetto4Arturo Ciccullo5Alberto Borghetti6Dipartimento di Sicurezza e Bioetica - Sezione di Malattie Infettive, Università Cattolica del Sacro Cuore, 00168 Rome, Italy; Corresponding author.Dipartimento di Sicurezza e Bioetica - Sezione di Malattie Infettive, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDipartimento di Sicurezza e Bioetica - Sezione di Malattie Infettive, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, ItalyDipartimento di Sicurezza e Bioetica - Sezione di Malattie Infettive, Università Cattolica del Sacro Cuore, 00168 Rome, Italy; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, ItalyInfectious Diseases Unit, San Salvatore Hospital, 67100 L'Aquila, ItalyDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, ItalySummary: We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation, not vaccinated for SARS-COV-2, hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit (ICU). The hospitalization was complicated by bacteraemic ventilator-associated pneumonia (VAP) caused by multidrug-resistant Acinetobacter baumannii (MDR-AB) isolated on pleural fluid culture, treated with colistin and cefiderocol for about 3 weeks. The molecular research of MDR-AB on transtracheal aspirate was negative following this therapy.The aim is to show the safety, efficacy and tolerability of colistin-based combination therapy with cefiderocol for Acinetobacter baumannii infection in HIV-infected patient.http://www.sciencedirect.com/science/article/pii/S2772431X23000096Acinetobacter baumanniicolistincefiderocolSARS-CoV-2HIV |
| spellingShingle | Rosa Anna Passerotto Francesco Lamanna Damiano Farinacci Alex Dusina Simona Di Giambenedetto Arturo Ciccullo Alberto Borghetti Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report Infectious Medicine Acinetobacter baumannii colistin cefiderocol SARS-CoV-2 HIV |
| title | Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report |
| title_full | Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report |
| title_fullStr | Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report |
| title_full_unstemmed | Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report |
| title_short | Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report |
| title_sort | ventilator associated pneumonia vap and pleural empyema caused by multidrug resistant acinetobacter baumannii in hiv and covid 19 infected patient a case report |
| topic | Acinetobacter baumannii colistin cefiderocol SARS-CoV-2 HIV |
| url | http://www.sciencedirect.com/science/article/pii/S2772431X23000096 |
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