An Improved Tat/Rev Induced Limiting Dilution Assay With Enhanced Sensitivity and Breadth of Detection

An Improved Tat/Rev Induced Limiting Dilution Assay With Enhanced Sensitivity and Breadth of Detection

Tat/Rev Induced Limiting Dilution Assay (TILDA) is instrumental in estimating the size of latent reservoirs of HIV-1. Here, we report an optimized TILDA containing a broader detection range compared to the reported methods and high sensitivity. Giving priority to sequence conservation, we positioned...

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Bibliographic Details
Main Authors: Kavita Mehta, Yuvrajsinh Gohil, Swarnima Mishra, Anish D’silva, Afzal Amanullah, Deepak Selvam, Neelam Pargain, Narendra Nala, G. N. Sanjeeva, Udaykumar Ranga
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
latent reservoir
HIV latency
HIV-1
TILDA
transcriptional silence
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.715644/full

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