Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus

Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus

The etiology of dental anomalies is multifactorial; and genetic and environmental factors that affect the dental lamina have been implicated. We investigated two families of European ancestry in which males were affected by taurodontism, microdontia and dens invaginatus. In both families, males were...

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Main Authors: Lord J.J. Gowans, Sophia Cameron-Christie, Rebecca L. Slayton, Tamara Busch, Miguel Romero-Bustillos, Steven Eliason, Mason Sweat, Nara Sobreira, Wenjie Yu, Piranit N. Kantaputra, Elizabeth Wohler, Wasiu Lanre Adeyemo, Salil A. Lachke, Deepti Anand, Collen Campbell, Bernadette K. Drummond, David M. Markie, W. Jansen van Vuuren, L. Jansen van Vuuren, Paul S. Casamassimo, Ronald Ettinger, Arwa Owais, I. van Staden, Brad A. Amendt, Adebowale A. Adeyemo, Jeffrey C. Murray, Stephen P. Robertson, Azeez Butali
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Genetics
Subjects:
exome sequencing
X-linked recessive
microdontia
taurodontism
dens invaginatus
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00800/full

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