Genetic diversity of <it>Plasmodium vivax </it>in Kolkata, India
<p>Abstract</p> <p>Background</p> <p><it>Plasmodium vivax </it>malaria accounts for approximately 60% of malaria cases in Kolkata, India. There has been limited information on the genotypic polymorphism of <it>P. vivax </it>in this malaria endemi...
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Format: | Article |
Language: | English |
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BMC
2006-08-01
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Series: | Malaria Journal |
Online Access: | http://www.malariajournal.com/content/5/1/71 |
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author | Day Nick PJ Addy Manjulika Maji Ardhendu Tonomsing Naowarat Nontprasert Apichart Chotivanich Kesinee Nandy Amitabha Imwong Mallika Kim Jung-Ryong White Nicholas J Pukrittayakamee Sasithon |
author_facet | Day Nick PJ Addy Manjulika Maji Ardhendu Tonomsing Naowarat Nontprasert Apichart Chotivanich Kesinee Nandy Amitabha Imwong Mallika Kim Jung-Ryong White Nicholas J Pukrittayakamee Sasithon |
author_sort | Day Nick PJ |
collection | DOAJ |
description | <p>Abstract</p> <p>Background</p> <p><it>Plasmodium vivax </it>malaria accounts for approximately 60% of malaria cases in Kolkata, India. There has been limited information on the genotypic polymorphism of <it>P. vivax </it>in this malaria endemic area. Three highly polymorphic and single copy genes were selected for a study of genetic diversity in Kolkata strains.</p> <p>Methods</p> <p>Blood from 151 patients with <it>P. vivax </it>infection diagnosed in Kolkata between April 2003 and September 2004 was genotyped at three polymorphic loci: the <it>P. vivax </it>circumsporozoite protein (<it>pvcs</it>), the merozoite surface protein 1 (<it>pvmsp</it>1) and the merozoite surface protein 3-alpha (<it>pvmsp</it>3-alpha).</p> <p>Results</p> <p>Analysis of these three genetic markers revealed that <it>P. vivax </it>populations in Kolkata are highly diverse. A large number of distinguishable alleles were found from three genetic markers: 11 for <it>pvcs</it>, 35 for <it>pvmsp</it>1 and 37 for <it>pvmsp</it>3-alpha. These were, in general, randomly distributed amongst the isolates. Among the 151 isolates, 142 unique genotypes were detected the commonest genotype at a frequency of less than 2% (3/151). The overall rate of mixed genotype infections was 10.6%.</p> <p>Conclusion</p> <p>These results indicate that the <it>P. vivax </it>parasite population is highly diverse in Kolkata, despite the low level of transmission. The genotyping protocols used in this study may be useful for differentiating re-infection from relapse and recrudescence in studies assessing of malarial drug efficacy in vivax malaria.</p> |
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format | Article |
id | doaj.art-dc7c7fcd3d874ea29ce78f920203c55f |
institution | Directory Open Access Journal |
issn | 1475-2875 |
language | English |
last_indexed | 2024-12-12T02:21:56Z |
publishDate | 2006-08-01 |
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series | Malaria Journal |
spelling | doaj.art-dc7c7fcd3d874ea29ce78f920203c55f2022-12-22T00:41:39ZengBMCMalaria Journal1475-28752006-08-01517110.1186/1475-2875-5-71Genetic diversity of <it>Plasmodium vivax </it>in Kolkata, IndiaDay Nick PJAddy ManjulikaMaji ArdhenduTonomsing NaowaratNontprasert ApichartChotivanich KesineeNandy AmitabhaImwong MallikaKim Jung-RyongWhite Nicholas JPukrittayakamee Sasithon<p>Abstract</p> <p>Background</p> <p><it>Plasmodium vivax </it>malaria accounts for approximately 60% of malaria cases in Kolkata, India. There has been limited information on the genotypic polymorphism of <it>P. vivax </it>in this malaria endemic area. Three highly polymorphic and single copy genes were selected for a study of genetic diversity in Kolkata strains.</p> <p>Methods</p> <p>Blood from 151 patients with <it>P. vivax </it>infection diagnosed in Kolkata between April 2003 and September 2004 was genotyped at three polymorphic loci: the <it>P. vivax </it>circumsporozoite protein (<it>pvcs</it>), the merozoite surface protein 1 (<it>pvmsp</it>1) and the merozoite surface protein 3-alpha (<it>pvmsp</it>3-alpha).</p> <p>Results</p> <p>Analysis of these three genetic markers revealed that <it>P. vivax </it>populations in Kolkata are highly diverse. A large number of distinguishable alleles were found from three genetic markers: 11 for <it>pvcs</it>, 35 for <it>pvmsp</it>1 and 37 for <it>pvmsp</it>3-alpha. These were, in general, randomly distributed amongst the isolates. Among the 151 isolates, 142 unique genotypes were detected the commonest genotype at a frequency of less than 2% (3/151). The overall rate of mixed genotype infections was 10.6%.</p> <p>Conclusion</p> <p>These results indicate that the <it>P. vivax </it>parasite population is highly diverse in Kolkata, despite the low level of transmission. The genotyping protocols used in this study may be useful for differentiating re-infection from relapse and recrudescence in studies assessing of malarial drug efficacy in vivax malaria.</p>http://www.malariajournal.com/content/5/1/71 |
spellingShingle | Day Nick PJ Addy Manjulika Maji Ardhendu Tonomsing Naowarat Nontprasert Apichart Chotivanich Kesinee Nandy Amitabha Imwong Mallika Kim Jung-Ryong White Nicholas J Pukrittayakamee Sasithon Genetic diversity of <it>Plasmodium vivax </it>in Kolkata, India Malaria Journal |
title | Genetic diversity of <it>Plasmodium vivax </it>in Kolkata, India |
title_full | Genetic diversity of <it>Plasmodium vivax </it>in Kolkata, India |
title_fullStr | Genetic diversity of <it>Plasmodium vivax </it>in Kolkata, India |
title_full_unstemmed | Genetic diversity of <it>Plasmodium vivax </it>in Kolkata, India |
title_short | Genetic diversity of <it>Plasmodium vivax </it>in Kolkata, India |
title_sort | genetic diversity of it plasmodium vivax it in kolkata india |
url | http://www.malariajournal.com/content/5/1/71 |
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