Dendritic Cells and HIV-1 Trans-Infection
Dendritic cells initiate and sustain immune responses by migrating to sites of pathogenic insult, transporting antigens to lymphoid tissues and signaling immune specific activation of T cells through the formation of the immunological synapse. Dendritic cells can also transfer intact, infectious HIV...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-08-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/2/8/1704/ |
| _version_ | 1818964365698662400 |
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| author | David McDonald |
| author_facet | David McDonald |
| author_sort | David McDonald |
| collection | DOAJ |
| description | Dendritic cells initiate and sustain immune responses by migrating to sites of pathogenic insult, transporting antigens to lymphoid tissues and signaling immune specific activation of T cells through the formation of the immunological synapse. Dendritic cells can also transfer intact, infectious HIV-1 to CD4 T cells through an analogous structure, the infectious synapse. This replication independent mode of HIV-1 transmission, known as trans-infection, greatly increases T cell infection in vitro and is thought to contribute to viral dissemination in vivo. This review outlines the recent data defining the mechanisms of trans-infection and provides a context for the potential contribution of trans-infection in HIV-1 disease. |
| first_indexed | 2024-12-20T12:59:58Z |
| format | Article |
| id | doaj.art-dc7e02f148a84a228291d33cf5d1164a |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-20T12:59:58Z |
| publishDate | 2010-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-dc7e02f148a84a228291d33cf5d1164a2022-12-21T19:39:57ZengMDPI AGViruses1999-49152010-08-01281704171710.3390/v2081704Dendritic Cells and HIV-1 Trans-InfectionDavid McDonaldDendritic cells initiate and sustain immune responses by migrating to sites of pathogenic insult, transporting antigens to lymphoid tissues and signaling immune specific activation of T cells through the formation of the immunological synapse. Dendritic cells can also transfer intact, infectious HIV-1 to CD4 T cells through an analogous structure, the infectious synapse. This replication independent mode of HIV-1 transmission, known as trans-infection, greatly increases T cell infection in vitro and is thought to contribute to viral dissemination in vivo. This review outlines the recent data defining the mechanisms of trans-infection and provides a context for the potential contribution of trans-infection in HIV-1 disease.http://www.mdpi.com/1999-4915/2/8/1704/myeloid dendritic cellC-type lectin receptorantigen presentationtrans-infectioninfectious synapse |
| spellingShingle | David McDonald Dendritic Cells and HIV-1 Trans-Infection Viruses myeloid dendritic cell C-type lectin receptor antigen presentation trans-infection infectious synapse |
| title | Dendritic Cells and HIV-1 Trans-Infection |
| title_full | Dendritic Cells and HIV-1 Trans-Infection |
| title_fullStr | Dendritic Cells and HIV-1 Trans-Infection |
| title_full_unstemmed | Dendritic Cells and HIV-1 Trans-Infection |
| title_short | Dendritic Cells and HIV-1 Trans-Infection |
| title_sort | dendritic cells and hiv 1 trans infection |
| topic | myeloid dendritic cell C-type lectin receptor antigen presentation trans-infection infectious synapse |
| url | http://www.mdpi.com/1999-4915/2/8/1704/ |
| work_keys_str_mv | AT davidmcdonald dendriticcellsandhiv1transinfection |