SPRTN patient variants cause global-genome DNA-protein crosslink repair defects
DNA-protein crosslinks (DPCs) are toxic DNA lesions which threaten genome stability. Here, the authors develop a method to track the fate of DPCs in cells and identify a role for the SPRTN protease in replication-independent DPC repair.
Bibliographic Details
| Main Authors: |
Pedro Weickert,
Hao-Yi Li,
Maximilian J. Götz,
Sophie Dürauer,
Denitsa Yaneva,
Shubo Zhao,
Jacqueline Cordes,
Aleida C. Acampora,
Ignasi Forne,
Axel Imhof,
Julian Stingele |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-023-35988-1
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