SPRTN patient variants cause global-genome DNA-protein crosslink repair defects
DNA-protein crosslinks (DPCs) are toxic DNA lesions which threaten genome stability. Here, the authors develop a method to track the fate of DPCs in cells and identify a role for the SPRTN protease in replication-independent DPC repair.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-35988-1 |
| _version_ | 1797945840286826496 |
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| author | Pedro Weickert Hao-Yi Li Maximilian J. Götz Sophie Dürauer Denitsa Yaneva Shubo Zhao Jacqueline Cordes Aleida C. Acampora Ignasi Forne Axel Imhof Julian Stingele |
| author_facet | Pedro Weickert Hao-Yi Li Maximilian J. Götz Sophie Dürauer Denitsa Yaneva Shubo Zhao Jacqueline Cordes Aleida C. Acampora Ignasi Forne Axel Imhof Julian Stingele |
| author_sort | Pedro Weickert |
| collection | DOAJ |
| description | DNA-protein crosslinks (DPCs) are toxic DNA lesions which threaten genome stability. Here, the authors develop a method to track the fate of DPCs in cells and identify a role for the SPRTN protease in replication-independent DPC repair. |
| first_indexed | 2024-04-10T21:01:29Z |
| format | Article |
| id | doaj.art-dc7e3a77ff704d98b30b8ecc3d84505f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T21:01:29Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-dc7e3a77ff704d98b30b8ecc3d84505f2023-01-22T12:19:21ZengNature PortfolioNature Communications2041-17232023-01-0114111410.1038/s41467-023-35988-1SPRTN patient variants cause global-genome DNA-protein crosslink repair defectsPedro Weickert0Hao-Yi Li1Maximilian J. Götz2Sophie Dürauer3Denitsa Yaneva4Shubo Zhao5Jacqueline Cordes6Aleida C. Acampora7Ignasi Forne8Axel Imhof9Julian Stingele10Department of Biochemistry, Ludwig-Maximilians-UniversityDepartment of Biochemistry, Ludwig-Maximilians-UniversityDepartment of Biochemistry, Ludwig-Maximilians-UniversityDepartment of Biochemistry, Ludwig-Maximilians-UniversityDepartment of Biochemistry, Ludwig-Maximilians-UniversityDepartment of Biochemistry, Ludwig-Maximilians-UniversityDepartment of Biochemistry, Ludwig-Maximilians-UniversityDepartment of Biochemistry, Ludwig-Maximilians-UniversityProtein Analysis Unit (ZfP), BioMedical Center (BMC), Ludwig-Maximilians-UniversityProtein Analysis Unit (ZfP), BioMedical Center (BMC), Ludwig-Maximilians-UniversityDepartment of Biochemistry, Ludwig-Maximilians-UniversityDNA-protein crosslinks (DPCs) are toxic DNA lesions which threaten genome stability. Here, the authors develop a method to track the fate of DPCs in cells and identify a role for the SPRTN protease in replication-independent DPC repair.https://doi.org/10.1038/s41467-023-35988-1 |
| spellingShingle | Pedro Weickert Hao-Yi Li Maximilian J. Götz Sophie Dürauer Denitsa Yaneva Shubo Zhao Jacqueline Cordes Aleida C. Acampora Ignasi Forne Axel Imhof Julian Stingele SPRTN patient variants cause global-genome DNA-protein crosslink repair defects Nature Communications |
| title | SPRTN patient variants cause global-genome DNA-protein crosslink repair defects |
| title_full | SPRTN patient variants cause global-genome DNA-protein crosslink repair defects |
| title_fullStr | SPRTN patient variants cause global-genome DNA-protein crosslink repair defects |
| title_full_unstemmed | SPRTN patient variants cause global-genome DNA-protein crosslink repair defects |
| title_short | SPRTN patient variants cause global-genome DNA-protein crosslink repair defects |
| title_sort | sprtn patient variants cause global genome dna protein crosslink repair defects |
| url | https://doi.org/10.1038/s41467-023-35988-1 |
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