A gene based combination test using GWAS summary data

A gene based combination test using GWAS summary data

Abstract Background Gene-based association tests provide a useful alternative and complement to the usual single marker association tests, especially in genome-wide association studies (GWAS). The way of weighting for variants in a gene plays an important role in boosting the power of a gene-based a...

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Bibliographic Details
Main Authors: Jianjun Zhang, Xiaoyu Liang, Samantha Gonzales, Jianguo Liu, Xiaoyi Raymond Gao, Xuexia Wang
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Bioinformatics
Subjects:
Combination test
Score test
Burden test
Weighted sum of squared score test
Weighted sum statistic
Online Access:https://doi.org/10.1186/s12859-022-05114-x

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