Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis
Summary: Many patients with visceral inflammation develop pain and psychiatric comorbidities such as major depressive disorder, worsening the quality of life and increasing the risk of suicide. Here we show that neuroimmune activation in mice with dextran sodium sulfate-induced colitis is accompanie...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-06-01
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| Series: | iScience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900421930149X |
| _version_ | 1811263851717459968 |
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| author | Vinicius M. Gadotti Graciela Andonegui Zizhen Zhang Said M'Dahoma Cristiane H. Baggio Lina Chen Lilian Basso Christophe Altier Wallace K. MacNaughton Paul Kubes Gerald W. Zamponi |
| author_facet | Vinicius M. Gadotti Graciela Andonegui Zizhen Zhang Said M'Dahoma Cristiane H. Baggio Lina Chen Lilian Basso Christophe Altier Wallace K. MacNaughton Paul Kubes Gerald W. Zamponi |
| author_sort | Vinicius M. Gadotti |
| collection | DOAJ |
| description | Summary: Many patients with visceral inflammation develop pain and psychiatric comorbidities such as major depressive disorder, worsening the quality of life and increasing the risk of suicide. Here we show that neuroimmune activation in mice with dextran sodium sulfate-induced colitis is accompanied by the development of pain and depressive behaviors. Importantly, treatment with the flavonoid luteolin prevented both neuroimmune responses and behavioral abnormalities, suggesting a new potential therapeutic approach for patients with inflammatory bowel diseases. : Pathophysiology; Behavioral Neuroscience; Cellular Neuroscience; Immunity Subject Areas: Pathophysiology, Behavioral Neuroscience, Cellular Neuroscience, Immunity |
| first_indexed | 2024-04-12T19:52:32Z |
| format | Article |
| id | doaj.art-dc7ebaf0f7984e69ae4a70378c6bccf8 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-12T19:52:32Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-dc7ebaf0f7984e69ae4a70378c6bccf82022-12-22T03:18:48ZengElsevieriScience2589-00422019-06-01161221Neuroimmune Responses Mediate Depression-Related Behaviors following Acute ColitisVinicius M. Gadotti0Graciela Andonegui1Zizhen Zhang2Said M'Dahoma3Cristiane H. Baggio4Lina Chen5Lilian Basso6Christophe Altier7Wallace K. MacNaughton8Paul Kubes9Gerald W. Zamponi10Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Corresponding authorDepartment of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Physiology and Pharmacology, Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Corresponding authorSummary: Many patients with visceral inflammation develop pain and psychiatric comorbidities such as major depressive disorder, worsening the quality of life and increasing the risk of suicide. Here we show that neuroimmune activation in mice with dextran sodium sulfate-induced colitis is accompanied by the development of pain and depressive behaviors. Importantly, treatment with the flavonoid luteolin prevented both neuroimmune responses and behavioral abnormalities, suggesting a new potential therapeutic approach for patients with inflammatory bowel diseases. : Pathophysiology; Behavioral Neuroscience; Cellular Neuroscience; Immunity Subject Areas: Pathophysiology, Behavioral Neuroscience, Cellular Neuroscience, Immunityhttp://www.sciencedirect.com/science/article/pii/S258900421930149X |
| spellingShingle | Vinicius M. Gadotti Graciela Andonegui Zizhen Zhang Said M'Dahoma Cristiane H. Baggio Lina Chen Lilian Basso Christophe Altier Wallace K. MacNaughton Paul Kubes Gerald W. Zamponi Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis iScience |
| title | Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis |
| title_full | Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis |
| title_fullStr | Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis |
| title_full_unstemmed | Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis |
| title_short | Neuroimmune Responses Mediate Depression-Related Behaviors following Acute Colitis |
| title_sort | neuroimmune responses mediate depression related behaviors following acute colitis |
| url | http://www.sciencedirect.com/science/article/pii/S258900421930149X |
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