Particulate matter 2.5, metropolitan status, and heart failure outcomes in US counties: A nationwide ecologic analysis.
The relationship between particulate matter with a diameter of 2.5 micrometers or less (PM2.5) and heart failure (HF) hospitalizations and mortality in the US is unclear. Prior studies are limited to studying the effects of daily PM2.5 exposure on HF hospitalizations in specific geographic regions....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0279777 |
| _version_ | 1797944032996884480 |
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| author | Edward W Chen Khansa Ahmad Sebhat Erqou Wen-Chih Wu |
| author_facet | Edward W Chen Khansa Ahmad Sebhat Erqou Wen-Chih Wu |
| author_sort | Edward W Chen |
| collection | DOAJ |
| description | The relationship between particulate matter with a diameter of 2.5 micrometers or less (PM2.5) and heart failure (HF) hospitalizations and mortality in the US is unclear. Prior studies are limited to studying the effects of daily PM2.5 exposure on HF hospitalizations in specific geographic regions. Because PM2.5 can vary by geography, this study examines the effects of annual ambient PM2.5 exposure on HF hospitalizations and mortality at a county-level across the US. A cross-sectional analysis of county-level ambient PM2.5 concentration, HF hospitalizations, and HF mortality across 3135 US counties nationwide was performed, adjusting for county-level demographics, socioeconomic factors, comorbidities, and healthcare-associated behaviors. There was a moderate correlation between county PM2.5 and HF hospitalization among Medicare beneficiaries (r = 0.41) and a weak correlation between county PM2.5 and HF mortality (r = 0.08) (p-values < 0.01). After adjustment for various county level covariates, every 1 ug/m3 increase in annual PM2.5 concentration was associated with an increase of 0.51 HF Hospitalizations/1,000 Medicare Beneficiaries and 0.74 HF deaths/100,000 residents (p-values < 0.05). In addition, the relationship between PM2.5 and HF hospitalizations was similar when factoring in metropolitan status of the counties. In conclusion, increased ambient PM2.5 concentration level was associated with increased incidence of HF hospitalizations and mortality at the county level across the US. This calls for future studies exploring policies that reduce ambient particulate matter pollution and their downstream effects on potentially improving HF outcomes. |
| first_indexed | 2024-04-10T20:33:22Z |
| format | Article |
| id | doaj.art-dc7ebd1f522e4286b707f025a03599ac |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T20:33:22Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dc7ebd1f522e4286b707f025a03599ac2023-01-25T05:32:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011712e027977710.1371/journal.pone.0279777Particulate matter 2.5, metropolitan status, and heart failure outcomes in US counties: A nationwide ecologic analysis.Edward W ChenKhansa AhmadSebhat ErqouWen-Chih WuThe relationship between particulate matter with a diameter of 2.5 micrometers or less (PM2.5) and heart failure (HF) hospitalizations and mortality in the US is unclear. Prior studies are limited to studying the effects of daily PM2.5 exposure on HF hospitalizations in specific geographic regions. Because PM2.5 can vary by geography, this study examines the effects of annual ambient PM2.5 exposure on HF hospitalizations and mortality at a county-level across the US. A cross-sectional analysis of county-level ambient PM2.5 concentration, HF hospitalizations, and HF mortality across 3135 US counties nationwide was performed, adjusting for county-level demographics, socioeconomic factors, comorbidities, and healthcare-associated behaviors. There was a moderate correlation between county PM2.5 and HF hospitalization among Medicare beneficiaries (r = 0.41) and a weak correlation between county PM2.5 and HF mortality (r = 0.08) (p-values < 0.01). After adjustment for various county level covariates, every 1 ug/m3 increase in annual PM2.5 concentration was associated with an increase of 0.51 HF Hospitalizations/1,000 Medicare Beneficiaries and 0.74 HF deaths/100,000 residents (p-values < 0.05). In addition, the relationship between PM2.5 and HF hospitalizations was similar when factoring in metropolitan status of the counties. In conclusion, increased ambient PM2.5 concentration level was associated with increased incidence of HF hospitalizations and mortality at the county level across the US. This calls for future studies exploring policies that reduce ambient particulate matter pollution and their downstream effects on potentially improving HF outcomes.https://doi.org/10.1371/journal.pone.0279777 |
| spellingShingle | Edward W Chen Khansa Ahmad Sebhat Erqou Wen-Chih Wu Particulate matter 2.5, metropolitan status, and heart failure outcomes in US counties: A nationwide ecologic analysis. PLoS ONE |
| title | Particulate matter 2.5, metropolitan status, and heart failure outcomes in US counties: A nationwide ecologic analysis. |
| title_full | Particulate matter 2.5, metropolitan status, and heart failure outcomes in US counties: A nationwide ecologic analysis. |
| title_fullStr | Particulate matter 2.5, metropolitan status, and heart failure outcomes in US counties: A nationwide ecologic analysis. |
| title_full_unstemmed | Particulate matter 2.5, metropolitan status, and heart failure outcomes in US counties: A nationwide ecologic analysis. |
| title_short | Particulate matter 2.5, metropolitan status, and heart failure outcomes in US counties: A nationwide ecologic analysis. |
| title_sort | particulate matter 2 5 metropolitan status and heart failure outcomes in us counties a nationwide ecologic analysis |
| url | https://doi.org/10.1371/journal.pone.0279777 |
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