Subclinical Atherosclerosis, Vascular Risk Factors, and White Matter Alterations in Diffusion Tensor Imaging Findings of Older Adults With Cardiometabolic Diseases
White matter abnormalities may reflect cerebral microvessel disease. Diffusion tensor imaging (DTI) can help detect early changes in white matter integrity in each tract. However, studies investigating the relationship between subclinical atherosclerosis markers and white matter alterations in DTI f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.712385/full |
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| author | Yoshiaki Tamura Keigo Shimoji Joji Ishikawa Yoshinori Matsuo So Watanabe Hisae Takahashi Shugo Zen Aya Tachibana Takuya Omura Remi Kodera Kazuhito Oba Kenji Toyoshima Yuko Chiba Aya M. Tokumaru Atsushi Araki |
| author_facet | Yoshiaki Tamura Keigo Shimoji Joji Ishikawa Yoshinori Matsuo So Watanabe Hisae Takahashi Shugo Zen Aya Tachibana Takuya Omura Remi Kodera Kazuhito Oba Kenji Toyoshima Yuko Chiba Aya M. Tokumaru Atsushi Araki |
| author_sort | Yoshiaki Tamura |
| collection | DOAJ |
| description | White matter abnormalities may reflect cerebral microvessel disease. Diffusion tensor imaging (DTI) can help detect early changes in white matter integrity in each tract. However, studies investigating the relationship between subclinical atherosclerosis markers and white matter alterations in DTI findings are limited. This study aimed to examine associations between cardiovascular risk factors and indices of subclinical atherosclerosis—ankle brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and carotid artery intima-media thickness (IMT)—and altered white matter integrity in older patients. A total of 224 patients (aged ≥65 years) with cardiometabolic disease who underwent magnetic resonance imaging (MRI) and either plethysmography or cervical ultrasound at the start of the 3-year observational study period were included in this study. We measured fractional anisotropy (FA) and mean diffusivity (MD), which are indices of white matter integrity in seven white matter tracts. In a univariate analysis, lower ABI and higher baPWV values were associated with FA or MD abnormalities in several tracts, whereas IMT was scarcely associated with such change. In addition, high blood pressure and glycoalbumin/glycohemoglobin ratio (GA/HbA1c) and low body mass index (BMI) and triglyceride (TG) levels were associated with FA or MD abnormalities. In a multivariate analysis adjusted for age, sex, BMI, diastolic blood pressure, TG, and GA/HbA1c, the associations between ABI and FA or MD remained in all of either side of the following tracts: anterior thalamic radiation, forceps minor, inferior frontooccipital fasciculus (p < 0.001 for all) and superior longitudinal fasciculus (SLF; p < 0.05), whereas most of those between baPWV and FA or MD disappeared except for SLF (p < 0.05). These results indicate that low ABI could be an indicator of white matter abnormalities. |
| first_indexed | 2024-12-17T13:15:06Z |
| format | Article |
| id | doaj.art-dc81781fb4ab484883320e5a364731a4 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-17T13:15:06Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-dc81781fb4ab484883320e5a364731a42022-12-21T21:47:01ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-08-011310.3389/fnagi.2021.712385712385Subclinical Atherosclerosis, Vascular Risk Factors, and White Matter Alterations in Diffusion Tensor Imaging Findings of Older Adults With Cardiometabolic DiseasesYoshiaki Tamura0Keigo Shimoji1Joji Ishikawa2Yoshinori Matsuo3So Watanabe4Hisae Takahashi5Shugo Zen6Aya Tachibana7Takuya Omura8Remi Kodera9Kazuhito Oba10Kenji Toyoshima11Yuko Chiba12Aya M. Tokumaru13Atsushi Araki14Department of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Cardiology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanDepartment of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, JapanWhite matter abnormalities may reflect cerebral microvessel disease. Diffusion tensor imaging (DTI) can help detect early changes in white matter integrity in each tract. However, studies investigating the relationship between subclinical atherosclerosis markers and white matter alterations in DTI findings are limited. This study aimed to examine associations between cardiovascular risk factors and indices of subclinical atherosclerosis—ankle brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and carotid artery intima-media thickness (IMT)—and altered white matter integrity in older patients. A total of 224 patients (aged ≥65 years) with cardiometabolic disease who underwent magnetic resonance imaging (MRI) and either plethysmography or cervical ultrasound at the start of the 3-year observational study period were included in this study. We measured fractional anisotropy (FA) and mean diffusivity (MD), which are indices of white matter integrity in seven white matter tracts. In a univariate analysis, lower ABI and higher baPWV values were associated with FA or MD abnormalities in several tracts, whereas IMT was scarcely associated with such change. In addition, high blood pressure and glycoalbumin/glycohemoglobin ratio (GA/HbA1c) and low body mass index (BMI) and triglyceride (TG) levels were associated with FA or MD abnormalities. In a multivariate analysis adjusted for age, sex, BMI, diastolic blood pressure, TG, and GA/HbA1c, the associations between ABI and FA or MD remained in all of either side of the following tracts: anterior thalamic radiation, forceps minor, inferior frontooccipital fasciculus (p < 0.001 for all) and superior longitudinal fasciculus (SLF; p < 0.05), whereas most of those between baPWV and FA or MD disappeared except for SLF (p < 0.05). These results indicate that low ABI could be an indicator of white matter abnormalities.https://www.frontiersin.org/articles/10.3389/fnagi.2021.712385/fulldiffusion tensor imagingatherosclerosisbrachial-ankle pulse wave velocityintima-media thicknessankle brachial index |
| spellingShingle | Yoshiaki Tamura Keigo Shimoji Joji Ishikawa Yoshinori Matsuo So Watanabe Hisae Takahashi Shugo Zen Aya Tachibana Takuya Omura Remi Kodera Kazuhito Oba Kenji Toyoshima Yuko Chiba Aya M. Tokumaru Atsushi Araki Subclinical Atherosclerosis, Vascular Risk Factors, and White Matter Alterations in Diffusion Tensor Imaging Findings of Older Adults With Cardiometabolic Diseases Frontiers in Aging Neuroscience diffusion tensor imaging atherosclerosis brachial-ankle pulse wave velocity intima-media thickness ankle brachial index |
| title | Subclinical Atherosclerosis, Vascular Risk Factors, and White Matter Alterations in Diffusion Tensor Imaging Findings of Older Adults With Cardiometabolic Diseases |
| title_full | Subclinical Atherosclerosis, Vascular Risk Factors, and White Matter Alterations in Diffusion Tensor Imaging Findings of Older Adults With Cardiometabolic Diseases |
| title_fullStr | Subclinical Atherosclerosis, Vascular Risk Factors, and White Matter Alterations in Diffusion Tensor Imaging Findings of Older Adults With Cardiometabolic Diseases |
| title_full_unstemmed | Subclinical Atherosclerosis, Vascular Risk Factors, and White Matter Alterations in Diffusion Tensor Imaging Findings of Older Adults With Cardiometabolic Diseases |
| title_short | Subclinical Atherosclerosis, Vascular Risk Factors, and White Matter Alterations in Diffusion Tensor Imaging Findings of Older Adults With Cardiometabolic Diseases |
| title_sort | subclinical atherosclerosis vascular risk factors and white matter alterations in diffusion tensor imaging findings of older adults with cardiometabolic diseases |
| topic | diffusion tensor imaging atherosclerosis brachial-ankle pulse wave velocity intima-media thickness ankle brachial index |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.712385/full |
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