Developmental origins of adult diseases
There is considerable evidence for the fact that early life environment in human beings are associated with future development of various metabolic diseases. Fetal programming and perinatal events appear to exert effects on later life that are independent of environmental risk factors in adults. Our...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=4;spage=532;epage=541;aulast=Mathew |
| _version_ | 1828187579166490624 |
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| author | Vivek Mathew S Vageesh Ayyar |
| author_facet | Vivek Mathew S Vageesh Ayyar |
| author_sort | Vivek Mathew |
| collection | DOAJ |
| description | There is considerable evidence for the fact that early life environment in human beings are associated with future development of various metabolic diseases. Fetal programming and perinatal events appear to exert effects on later life that are independent of environmental risk factors in adults. Our understanding of the underlying mechanisms are limited and remains unclear. However several animal models and epidemiological studies have shown this association, and it is assumed secondary to the penalties of developmental plasticity. In this review, we amalgamate facts from several disciplines to support this hypothesis. |
| first_indexed | 2024-04-12T07:37:15Z |
| format | Article |
| id | doaj.art-dc82db9aa158409383b3b40fae3a3c71 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-04-12T07:37:15Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-dc82db9aa158409383b3b40fae3a3c712022-12-22T03:41:54ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002012-01-0116453254110.4103/2230-8210.98005Developmental origins of adult diseasesVivek MathewS Vageesh AyyarThere is considerable evidence for the fact that early life environment in human beings are associated with future development of various metabolic diseases. Fetal programming and perinatal events appear to exert effects on later life that are independent of environmental risk factors in adults. Our understanding of the underlying mechanisms are limited and remains unclear. However several animal models and epidemiological studies have shown this association, and it is assumed secondary to the penalties of developmental plasticity. In this review, we amalgamate facts from several disciplines to support this hypothesis.http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=4;spage=532;epage=541;aulast=MathewCoronary artery diseasecatch-up growthdevelopmental origins of adult diseaseepigeneticsintrauterine growth retardationshort for gestational agetype 2 diabetes mellitus |
| spellingShingle | Vivek Mathew S Vageesh Ayyar Developmental origins of adult diseases Indian Journal of Endocrinology and Metabolism Coronary artery disease catch-up growth developmental origins of adult disease epigenetics intrauterine growth retardation short for gestational age type 2 diabetes mellitus |
| title | Developmental origins of adult diseases |
| title_full | Developmental origins of adult diseases |
| title_fullStr | Developmental origins of adult diseases |
| title_full_unstemmed | Developmental origins of adult diseases |
| title_short | Developmental origins of adult diseases |
| title_sort | developmental origins of adult diseases |
| topic | Coronary artery disease catch-up growth developmental origins of adult disease epigenetics intrauterine growth retardation short for gestational age type 2 diabetes mellitus |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=4;spage=532;epage=541;aulast=Mathew |
| work_keys_str_mv | AT vivekmathew developmentaloriginsofadultdiseases AT svageeshayyar developmentaloriginsofadultdiseases |