Hypophoshatemia Incidence in Patients with Chronic Kidney Disease Treated with Intravenous Ferric Carboxymaltose and Factors Related to Hypophosphatemia
Aim:We aimed to find the incidence of hypophoshatemia and to investigate predictive factors for the development of hypophospahtemia in patients with chronic kidney disease (CKD) treated with intravenous ferric carboxymaltose (FCM).Methods:In our single center retrospective study, we included 43 adul...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2020-09-01
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| Series: | Haseki Tıp Bülteni |
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http://www.hasekidergisi.com/archives/archive-detail/article-preview/hypophoshatemia-ncidence-in-patients-with-chronic-/40229
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| _version_ | 1828025361334534144 |
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| author | Abdullah Şumnu Ali Erdem Dal |
| author_facet | Abdullah Şumnu Ali Erdem Dal |
| author_sort | Abdullah Şumnu |
| collection | DOAJ |
| description | Aim:We aimed to find the incidence of hypophoshatemia and to investigate predictive factors for the development of hypophospahtemia in patients with chronic kidney disease (CKD) treated with intravenous ferric carboxymaltose (FCM).Methods:In our single center retrospective study, we included 43 adult patients who were given FCM therapy after nephrology clinic admission. Thirty-three non-dialysis CKD patients constituded the CKD group. Control group consisted of 11 patients with the diagnosis of iron deficiency anemia and normal renal function. Patients with missing data on serum phosphorus level before and after treatment were excluded.Results:The average age of CKD group was 68.8±10.2 years (69% female). The average serum creatinin level and and estimated glomerular filtration rate were 2.3±1.1 mg/dL and 29.7±17.6 mL/min/1.73m2, respectively. After the first week following FCM treatment, five of 11 patients in the control group (44.5%) and three of 32 patients in the CKD group (9.4%) developed hypophosphatemia (p=0.008). On linear regression analysis, it was found that baseline phosphorus level was the single predictor of hypophosphatemia (p=0.006).Conclusion:Our study demonstrated that the incidence of hypophosphatemia associated with FCM treatment in CKD patients was compatible with the rates in the literature. Clinicians should be careful in FCM treatment especially in patients having low baseline phosphorus level. |
| first_indexed | 2024-04-10T13:00:59Z |
| format | Article |
| id | doaj.art-dc835f0877d647218936e8f955e93853 |
| institution | Directory Open Access Journal |
| issn | 1302-0072 2147-2688 |
| language | English |
| last_indexed | 2024-04-10T13:00:59Z |
| publishDate | 2020-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Haseki Tıp Bülteni |
| spelling | doaj.art-dc835f0877d647218936e8f955e938532023-02-15T16:13:13ZengGalenos YayineviHaseki Tıp Bülteni1302-00722147-26882020-09-0158433834310.4274/haseki.galenos.2020.594713049054Hypophoshatemia Incidence in Patients with Chronic Kidney Disease Treated with Intravenous Ferric Carboxymaltose and Factors Related to HypophosphatemiaAbdullah Şumnu0Ali Erdem Dal1 Medipol Üniversitesi Tıp Fakültesi, Nefroloji Bilim Dalı, İstanbul, Türkiye Medipol Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, İstanbul, Türkiye Aim:We aimed to find the incidence of hypophoshatemia and to investigate predictive factors for the development of hypophospahtemia in patients with chronic kidney disease (CKD) treated with intravenous ferric carboxymaltose (FCM).Methods:In our single center retrospective study, we included 43 adult patients who were given FCM therapy after nephrology clinic admission. Thirty-three non-dialysis CKD patients constituded the CKD group. Control group consisted of 11 patients with the diagnosis of iron deficiency anemia and normal renal function. Patients with missing data on serum phosphorus level before and after treatment were excluded.Results:The average age of CKD group was 68.8±10.2 years (69% female). The average serum creatinin level and and estimated glomerular filtration rate were 2.3±1.1 mg/dL and 29.7±17.6 mL/min/1.73m2, respectively. After the first week following FCM treatment, five of 11 patients in the control group (44.5%) and three of 32 patients in the CKD group (9.4%) developed hypophosphatemia (p=0.008). On linear regression analysis, it was found that baseline phosphorus level was the single predictor of hypophosphatemia (p=0.006).Conclusion:Our study demonstrated that the incidence of hypophosphatemia associated with FCM treatment in CKD patients was compatible with the rates in the literature. Clinicians should be careful in FCM treatment especially in patients having low baseline phosphorus level. http://www.hasekidergisi.com/archives/archive-detail/article-preview/hypophoshatemia-ncidence-in-patients-with-chronic-/40229 chronic kidney diseaseferric carboxymaltosehypophosphatemia |
| spellingShingle | Abdullah Şumnu Ali Erdem Dal Hypophoshatemia Incidence in Patients with Chronic Kidney Disease Treated with Intravenous Ferric Carboxymaltose and Factors Related to Hypophosphatemia Haseki Tıp Bülteni chronic kidney disease ferric carboxymaltose hypophosphatemia |
| title | Hypophoshatemia Incidence in Patients with Chronic Kidney Disease Treated with Intravenous Ferric Carboxymaltose and Factors Related to Hypophosphatemia |
| title_full | Hypophoshatemia Incidence in Patients with Chronic Kidney Disease Treated with Intravenous Ferric Carboxymaltose and Factors Related to Hypophosphatemia |
| title_fullStr | Hypophoshatemia Incidence in Patients with Chronic Kidney Disease Treated with Intravenous Ferric Carboxymaltose and Factors Related to Hypophosphatemia |
| title_full_unstemmed | Hypophoshatemia Incidence in Patients with Chronic Kidney Disease Treated with Intravenous Ferric Carboxymaltose and Factors Related to Hypophosphatemia |
| title_short | Hypophoshatemia Incidence in Patients with Chronic Kidney Disease Treated with Intravenous Ferric Carboxymaltose and Factors Related to Hypophosphatemia |
| title_sort | hypophoshatemia incidence in patients with chronic kidney disease treated with intravenous ferric carboxymaltose and factors related to hypophosphatemia |
| topic | chronic kidney disease ferric carboxymaltose hypophosphatemia |
| url |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/hypophoshatemia-ncidence-in-patients-with-chronic-/40229
|
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