Structural and Dynamic Differences between Calreticulin Mutants Associated with Essential Thrombocythemia

Structural and Dynamic Differences between Calreticulin Mutants Associated with Essential Thrombocythemia

Essential thrombocythemia (ET) is a blood cancer. ET is characterized by an overproduction of platelets that can lead to thrombosis formation. Platelet overproduction occurs in megakaryocytes through a signaling pathway that could involve JAK2, MPL, or CALR proteins. CALR mutations are associated wi...

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Bibliographic Details
Main Authors: Ragousandirane Radjasandirane, Alexandre G. de Brevern
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomolecules
Subjects:
CALR mutations
molecular dynamics
essential thrombocythemia
chronic myeloproliferative neoplasms
blood cancer
disulfide bonds
Online Access:https://www.mdpi.com/2218-273X/13/3/509

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