Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective
Cancer immunotherapy suppresses and destroys tumors by re-activating and sustaining the tumor-immune process, and thus improving the immune response of the body to the tumor. Immunotherapeutic strategies are showing promising results in pre-clinical and clinical trials, however, tumor microenvironme...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2020.1809559 |
| _version_ | 1819144301287833600 |
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| author | Huanrong Lan Wei Zhang Ketao Jin Yuyao Liu Zhen Wang |
| author_facet | Huanrong Lan Wei Zhang Ketao Jin Yuyao Liu Zhen Wang |
| author_sort | Huanrong Lan |
| collection | DOAJ |
| description | Cancer immunotherapy suppresses and destroys tumors by re-activating and sustaining the tumor-immune process, and thus improving the immune response of the body to the tumor. Immunotherapeutic strategies are showing promising results in pre-clinical and clinical trials, however, tumor microenvironment (TME) is extremely immunosuppressive. Thus, their translation from labs to clinics still faces issues. Recently, nanomaterial-based strategies have been developed to modulate the TME for robust immunotherapeutic responses. The combination of nanotechnology with immunotherapy potentiates the effectiveness of immunotherapy by increasing delivery and retention, and by reducing immunomodulation toxicity. This review aims to highlight the barriers offered by TME for hindering the efficiency of immunotherapy for cancer treatment. Next, we highlight various nano-carriers based strategies for modulating those barriers for achieving better therapeutic efficacy of cancer immunotherapy with higher safety. This review will add to the body of scientific knowledge and will be a good reference material for academia and industries. |
| first_indexed | 2024-12-22T12:39:57Z |
| format | Article |
| id | doaj.art-dc86eed0ad8b4c6c9ff0dcc0aff86127 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-22T12:39:57Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-dc86eed0ad8b4c6c9ff0dcc0aff861272022-12-21T18:25:29ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642020-01-012711248126210.1080/10717544.2020.18095591809559Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspectiveHuanrong Lan0Wei Zhang1Ketao Jin2Yuyao Liu3Zhen Wang4Department of Breast and Thyroid Surgery, Jinhua Hospital, Zhejiang University School of MedicineRehabilitation and Sports Medicine Research Institute of Zhejiang Province, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical CollegeDepartment of Colorectal Surgery, Jinhua Hospital, Zhejiang University School of MedicineDepartment of Colorectal Surgery, Jinhua Hospital, Zhejiang University School of MedicineRehabilitation and Sports Medicine Research Institute of Zhejiang Province, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical CollegeCancer immunotherapy suppresses and destroys tumors by re-activating and sustaining the tumor-immune process, and thus improving the immune response of the body to the tumor. Immunotherapeutic strategies are showing promising results in pre-clinical and clinical trials, however, tumor microenvironment (TME) is extremely immunosuppressive. Thus, their translation from labs to clinics still faces issues. Recently, nanomaterial-based strategies have been developed to modulate the TME for robust immunotherapeutic responses. The combination of nanotechnology with immunotherapy potentiates the effectiveness of immunotherapy by increasing delivery and retention, and by reducing immunomodulation toxicity. This review aims to highlight the barriers offered by TME for hindering the efficiency of immunotherapy for cancer treatment. Next, we highlight various nano-carriers based strategies for modulating those barriers for achieving better therapeutic efficacy of cancer immunotherapy with higher safety. This review will add to the body of scientific knowledge and will be a good reference material for academia and industries.http://dx.doi.org/10.1080/10717544.2020.1809559tumor microenvironmentimmunotherapynanotechnology |
| spellingShingle | Huanrong Lan Wei Zhang Ketao Jin Yuyao Liu Zhen Wang Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective Drug Delivery tumor microenvironment immunotherapy nanotechnology |
| title | Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective |
| title_full | Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective |
| title_fullStr | Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective |
| title_full_unstemmed | Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective |
| title_short | Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective |
| title_sort | modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy a review of current status and future perspective |
| topic | tumor microenvironment immunotherapy nanotechnology |
| url | http://dx.doi.org/10.1080/10717544.2020.1809559 |
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