Oxygen-supplied electrotherapy for enhanced photodynamic synergistic therapy overcomes hypoxia tumor microenvironment
Photodynamic therapy (PDT) has lately been identified as a promising anticancer method and gained tremendous interest due to its controllability, non-invasive nature, and negligible side effects. Nevertheless, the development of PDT is hampered by two factors. One is the insufficient tissue penetrat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-10-01
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| Series: | Nanophotonics |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/nanoph-2022-0417 |
| _version_ | 1797789040245735424 |
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| author | Li Chaozhou Tan Hui Lu Ruitao Qin Sainan Meng Xiangying Zhang Han Xie Zhongjian |
| author_facet | Li Chaozhou Tan Hui Lu Ruitao Qin Sainan Meng Xiangying Zhang Han Xie Zhongjian |
| author_sort | Li Chaozhou |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) has lately been identified as a promising anticancer method and gained tremendous interest due to its controllability, non-invasive nature, and negligible side effects. Nevertheless, the development of PDT is hampered by two factors. One is the insufficient tissue penetration of phototherapy laser, resulting in restricted treatment sites. Another one is the substantial dependence of reactive oxygen species (ROS) formation on oxygen concentration. Therefore, a strategy to promote ROS generation by overcoming the hypoxia microenvironment is critical to cancer therapy. Electrolysis of water is known to be a rapid and relatively secure method for producing oxygen. Thus, in this study, electrotherapy was introduced to alleviate the tumor hypoxia by producing oxygen in situ, hence boosting the PDT efficacy, namely E-PDT. Black phosphorus (BP) based nanomaterials were selected as clearable photosensitizers with outstanding PDT performance. Experiments conducted both in vitro and in vivo indicated that E-PDT performed superior therapeutic effects with the in situ generation of oxygen by electrotherapy compared with other groups. This work suggests a promising strategy for phototherapeutic anticancer efficiency enhancement. |
| first_indexed | 2024-03-13T01:45:07Z |
| format | Article |
| id | doaj.art-dc871128b9014205929963e1895153f1 |
| institution | Directory Open Access Journal |
| issn | 2192-8606 2192-8614 |
| language | English |
| last_indexed | 2024-03-13T01:45:07Z |
| publishDate | 2022-10-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Nanophotonics |
| spelling | doaj.art-dc871128b9014205929963e1895153f12023-07-03T10:20:07ZengDe GruyterNanophotonics2192-86062192-86142022-10-0111225077508810.1515/nanoph-2022-0417Oxygen-supplied electrotherapy for enhanced photodynamic synergistic therapy overcomes hypoxia tumor microenvironmentLi Chaozhou0Tan Hui1Lu Ruitao2Qin Sainan3Meng Xiangying4Zhang Han5Xie Zhongjian6International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen, 518060, P. R. ChinaRespiratory Department, Shenzhen Children’s Hospital, Shenzhen, 518038, ChinaShenzhen International Institute for Biomedical Research, Shenzhen, 518116, Guangdong, ChinaRespiratory Department, Shenzhen Children’s Hospital, Shenzhen, 518038, ChinaShenzhen International Institute for Biomedical Research, Shenzhen, 518116, Guangdong, ChinaInternational Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen, 518060, P. R. ChinaRespiratory Department, Shenzhen Children’s Hospital, Shenzhen, 518038, ChinaPhotodynamic therapy (PDT) has lately been identified as a promising anticancer method and gained tremendous interest due to its controllability, non-invasive nature, and negligible side effects. Nevertheless, the development of PDT is hampered by two factors. One is the insufficient tissue penetration of phototherapy laser, resulting in restricted treatment sites. Another one is the substantial dependence of reactive oxygen species (ROS) formation on oxygen concentration. Therefore, a strategy to promote ROS generation by overcoming the hypoxia microenvironment is critical to cancer therapy. Electrolysis of water is known to be a rapid and relatively secure method for producing oxygen. Thus, in this study, electrotherapy was introduced to alleviate the tumor hypoxia by producing oxygen in situ, hence boosting the PDT efficacy, namely E-PDT. Black phosphorus (BP) based nanomaterials were selected as clearable photosensitizers with outstanding PDT performance. Experiments conducted both in vitro and in vivo indicated that E-PDT performed superior therapeutic effects with the in situ generation of oxygen by electrotherapy compared with other groups. This work suggests a promising strategy for phototherapeutic anticancer efficiency enhancement.https://doi.org/10.1515/nanoph-2022-0417black phosphoruselectrotherapyphotodynamic therapyros |
| spellingShingle | Li Chaozhou Tan Hui Lu Ruitao Qin Sainan Meng Xiangying Zhang Han Xie Zhongjian Oxygen-supplied electrotherapy for enhanced photodynamic synergistic therapy overcomes hypoxia tumor microenvironment Nanophotonics black phosphorus electrotherapy photodynamic therapy ros |
| title | Oxygen-supplied electrotherapy for enhanced photodynamic synergistic therapy overcomes hypoxia tumor microenvironment |
| title_full | Oxygen-supplied electrotherapy for enhanced photodynamic synergistic therapy overcomes hypoxia tumor microenvironment |
| title_fullStr | Oxygen-supplied electrotherapy for enhanced photodynamic synergistic therapy overcomes hypoxia tumor microenvironment |
| title_full_unstemmed | Oxygen-supplied electrotherapy for enhanced photodynamic synergistic therapy overcomes hypoxia tumor microenvironment |
| title_short | Oxygen-supplied electrotherapy for enhanced photodynamic synergistic therapy overcomes hypoxia tumor microenvironment |
| title_sort | oxygen supplied electrotherapy for enhanced photodynamic synergistic therapy overcomes hypoxia tumor microenvironment |
| topic | black phosphorus electrotherapy photodynamic therapy ros |
| url | https://doi.org/10.1515/nanoph-2022-0417 |
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