Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis

Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis

Summary: AMP-activated protein kinase (AMPK) coordinates energy homeostasis during metabolic and energy stress. We report that the catalytic subunit isoform AMPK-α1 (but not α2) is cleaved by caspase-3 at an early stage during induction of apoptosis. AMPK-α1 cleavage occurs following Asp529, generat...

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Bibliographic Details
Main Authors: Anees Rahman Cheratta, Faisal Thayyullathil, Simon A. Hawley, Fiona A. Ross, Abdelmajdid Atrih, Douglas J. Lamont, Siraj Pallichankandy, Karthikeyan Subburayan, Ameer Alakkal, Rachid Rezgui, Alex Gray, D. Grahame Hardie, Sehamuddin Galadari
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722005253

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