Hybrid lineages of CD4+ T cells: a handbook update
CD4+ T lymphocytes have been classified into several lineages, according to their gene expression profiles and their effector responses. Interestingly, recent evidence is showing that many lineages could yield hybrid phenotypes with unique properties and functions. It has been reported that such hyb...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1344078/full |
| _version_ | 1827378837423390720 |
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| author | Antonio Bensussen José Antonio Torres-Magallanes Elena R. Álvarez-Buylla Elena R. Álvarez-Buylla Elena Roces de Álvarez-Buylla |
| author_facet | Antonio Bensussen José Antonio Torres-Magallanes Elena R. Álvarez-Buylla Elena R. Álvarez-Buylla Elena Roces de Álvarez-Buylla |
| author_sort | Antonio Bensussen |
| collection | DOAJ |
| description | CD4+ T lymphocytes have been classified into several lineages, according to their gene expression profiles and their effector responses. Interestingly, recent evidence is showing that many lineages could yield hybrid phenotypes with unique properties and functions. It has been reported that such hybrid lineages might underlie pathologies or may function as effector cells with protection capacities against molecular threats. In this work, we reviewed the characteristics of the hybrid lineages reported in the literature, in order to identify the expression profiles that characterize them and the markers that could be used to identify them. We also review the differentiation cues that elicit their hybrid origin and what is known about their physiological roles. |
| first_indexed | 2024-03-08T13:03:40Z |
| format | Article |
| id | doaj.art-dc89ff94034249f6b2726ab75e11e9a9 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T13:03:40Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-dc89ff94034249f6b2726ab75e11e9a92024-01-19T04:34:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-01-011510.3389/fimmu.2024.13440781344078Hybrid lineages of CD4+ T cells: a handbook updateAntonio Bensussen0José Antonio Torres-Magallanes1Elena R. Álvarez-Buylla2Elena R. Álvarez-Buylla3Elena Roces de Álvarez-Buylla4Laboratorio de Neuroendocrinología, Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, MexicoLaboratorio de Neuroendocrinología, Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, MexicoLaboratorio de Genética Molecular, Epigenética, Desarrollo y Evolución de Plantas, Instituto de Ecología, Universidad Nacional Autónoma de México, Ciudad de México, MexicoCentro de Ciencias de la Complejidad (C3), Universidad Nacional Autónoma de México, Ciudad de México, MexicoLaboratorio de Neuroendocrinología, Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, MexicoCD4+ T lymphocytes have been classified into several lineages, according to their gene expression profiles and their effector responses. Interestingly, recent evidence is showing that many lineages could yield hybrid phenotypes with unique properties and functions. It has been reported that such hybrid lineages might underlie pathologies or may function as effector cells with protection capacities against molecular threats. In this work, we reviewed the characteristics of the hybrid lineages reported in the literature, in order to identify the expression profiles that characterize them and the markers that could be used to identify them. We also review the differentiation cues that elicit their hybrid origin and what is known about their physiological roles.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1344078/fullCD4+ T cellshybrid lineagesplasticitydifferentiationimmune response |
| spellingShingle | Antonio Bensussen José Antonio Torres-Magallanes Elena R. Álvarez-Buylla Elena R. Álvarez-Buylla Elena Roces de Álvarez-Buylla Hybrid lineages of CD4+ T cells: a handbook update Frontiers in Immunology CD4+ T cells hybrid lineages plasticity differentiation immune response |
| title | Hybrid lineages of CD4+ T cells: a handbook update |
| title_full | Hybrid lineages of CD4+ T cells: a handbook update |
| title_fullStr | Hybrid lineages of CD4+ T cells: a handbook update |
| title_full_unstemmed | Hybrid lineages of CD4+ T cells: a handbook update |
| title_short | Hybrid lineages of CD4+ T cells: a handbook update |
| title_sort | hybrid lineages of cd4 t cells a handbook update |
| topic | CD4+ T cells hybrid lineages plasticity differentiation immune response |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1344078/full |
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