Obesity Affects Maternal and Neonatal HDL Metabolism and Function
Pregravid obesity is one of the major risk factors for pregnancy complications such as gestational diabetes mellitus (GDM) and an increased risk of cardiovascular events in children of affected mothers. However, the biological mechanisms that underpin these adverse outcomes are not well understood....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/1/199 |
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| author | Julia T. Stadler Mireille N. M. van Poppel Christian Wadsack Michael Holzer Anja Pammer David Simmons David Hill Gernot Desoye Gunther Marsche DALI Core Investigator Group |
| author_facet | Julia T. Stadler Mireille N. M. van Poppel Christian Wadsack Michael Holzer Anja Pammer David Simmons David Hill Gernot Desoye Gunther Marsche DALI Core Investigator Group |
| author_sort | Julia T. Stadler |
| collection | DOAJ |
| description | Pregravid obesity is one of the major risk factors for pregnancy complications such as gestational diabetes mellitus (GDM) and an increased risk of cardiovascular events in children of affected mothers. However, the biological mechanisms that underpin these adverse outcomes are not well understood. High-density lipoproteins (HDLs) are antiatherogenic by promoting the efflux of cholesterol from macrophages and by suppression of inflammation. Functional impairment of HDLs in obese and GDM-complicated pregnancies may have long-term effects on maternal and offspring health. In the present study, we assessed metrics of HDL function in sera of pregnant women with overweight/obesity of the DALI lifestyle trial (prepregnancy BMI ≥ 29 kg/m<sup>2</sup>) and women with normal weight (prepregnancy BMI < 25 kg/m<sup>2</sup>), as well as HDL functionalities in cord blood at delivery. We observed that pregravid obesity was associated with impaired serum antioxidative capacity and lecithin–cholesterol acyltransferase activity in both mothers and offspring, whereas maternal HDL cholesterol efflux capacity was increased. Interestingly, functionalities of maternal and fetal HDL correlated robustly. GDM did not significantly further alter the parameters of HDL function and metabolism in women with obesity, so obesity itself appears to have a major impact on HDL functionality in mothers and their offspring. |
| first_indexed | 2024-03-09T13:46:39Z |
| format | Article |
| id | doaj.art-dc8bc87061ee4335b8bfa7d701bba95b |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T13:46:39Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-dc8bc87061ee4335b8bfa7d701bba95b2023-11-30T20:59:43ZengMDPI AGAntioxidants2076-39212023-01-0112119910.3390/antiox12010199Obesity Affects Maternal and Neonatal HDL Metabolism and FunctionJulia T. Stadler0Mireille N. M. van Poppel1Christian Wadsack2Michael Holzer3Anja Pammer4David Simmons5David Hill6Gernot Desoye7Gunther Marsche8DALI Core Investigator GroupDivision of Pharmacology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, 8010 Graz, AustriaInstitute of Human Movement Science, Sport and Health, University of Graz, 8010 Graz, AustriaDepartment of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, AustriaDivision of Pharmacology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, 8010 Graz, AustriaDivision of Pharmacology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, 8010 Graz, AustriaMacarthur Clinical School, Western Sydney University, Sydney, NSW 2560, AustraliaLawson Health Research Institute, London, ON N6C 2R5, CanadaDepartment of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, AustriaDivision of Pharmacology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, 8010 Graz, AustriaPregravid obesity is one of the major risk factors for pregnancy complications such as gestational diabetes mellitus (GDM) and an increased risk of cardiovascular events in children of affected mothers. However, the biological mechanisms that underpin these adverse outcomes are not well understood. High-density lipoproteins (HDLs) are antiatherogenic by promoting the efflux of cholesterol from macrophages and by suppression of inflammation. Functional impairment of HDLs in obese and GDM-complicated pregnancies may have long-term effects on maternal and offspring health. In the present study, we assessed metrics of HDL function in sera of pregnant women with overweight/obesity of the DALI lifestyle trial (prepregnancy BMI ≥ 29 kg/m<sup>2</sup>) and women with normal weight (prepregnancy BMI < 25 kg/m<sup>2</sup>), as well as HDL functionalities in cord blood at delivery. We observed that pregravid obesity was associated with impaired serum antioxidative capacity and lecithin–cholesterol acyltransferase activity in both mothers and offspring, whereas maternal HDL cholesterol efflux capacity was increased. Interestingly, functionalities of maternal and fetal HDL correlated robustly. GDM did not significantly further alter the parameters of HDL function and metabolism in women with obesity, so obesity itself appears to have a major impact on HDL functionality in mothers and their offspring.https://www.mdpi.com/2076-3921/12/1/199obesitypregnancygestational diabetes mellituscholesterol efflux capacityparaoxonase-1LCAT |
| spellingShingle | Julia T. Stadler Mireille N. M. van Poppel Christian Wadsack Michael Holzer Anja Pammer David Simmons David Hill Gernot Desoye Gunther Marsche DALI Core Investigator Group Obesity Affects Maternal and Neonatal HDL Metabolism and Function Antioxidants obesity pregnancy gestational diabetes mellitus cholesterol efflux capacity paraoxonase-1 LCAT |
| title | Obesity Affects Maternal and Neonatal HDL Metabolism and Function |
| title_full | Obesity Affects Maternal and Neonatal HDL Metabolism and Function |
| title_fullStr | Obesity Affects Maternal and Neonatal HDL Metabolism and Function |
| title_full_unstemmed | Obesity Affects Maternal and Neonatal HDL Metabolism and Function |
| title_short | Obesity Affects Maternal and Neonatal HDL Metabolism and Function |
| title_sort | obesity affects maternal and neonatal hdl metabolism and function |
| topic | obesity pregnancy gestational diabetes mellitus cholesterol efflux capacity paraoxonase-1 LCAT |
| url | https://www.mdpi.com/2076-3921/12/1/199 |
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