Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
Krupa Kansara, Pal Patel, Ritesh K Shukla, Alok Pandya, Rishi Shanker, Ashutosh Kumar, Alok Dhawan Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Over the last decade, there has been growing interest in developing novel nanop...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-03-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/synthesis-of-biocompatible-iron-oxide-nanoparticles-as-a-drug-delivery-peer-reviewed-article-IJN |
| _version_ | 1818992247161487360 |
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| author | Kansara K Patel P Shukla RK Pandya A Shanker R Kumar A Dhawan A |
| author_facet | Kansara K Patel P Shukla RK Pandya A Shanker R Kumar A Dhawan A |
| author_sort | Kansara K |
| collection | DOAJ |
| description | Krupa Kansara, Pal Patel, Ritesh K Shukla, Alok Pandya, Rishi Shanker, Ashutosh Kumar, Alok Dhawan Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Over the last decade, there has been growing interest in developing novel nanoparticles (NPs) for biomedical applications. A safe-by-design approach was used in this study to synthesize biocompatible iron oxide NPs. The size of the particles obtained was ~100 nm. Although these NPs were significantly (P<0.05) internalized in MCF-7 (human breast adenocarcinoma cell line) cells, no adverse effect was observed in the cells as assessed by cytotoxicity assays (neutral red uptake and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) and cell cycle analysis. Our data demonstrate the potential of iron oxide NPs as a biocompatible carrier for targeted drug delivery. Keywords: biocompatible iron oxide nanoparticles, human breast adenocarcinoma cells, coprecipitation |
| first_indexed | 2024-12-20T20:23:07Z |
| format | Article |
| id | doaj.art-dc8ddd731d144cf985bb95d8e8546bef |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-20T20:23:07Z |
| publishDate | 2018-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-dc8ddd731d144cf985bb95d8e8546bef2022-12-21T19:27:32ZengDove Medical PressInternational Journal of Nanomedicine1178-20132018-03-01Volume 13798237252Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicleKansara KPatel PShukla RKPandya AShanker RKumar ADhawan AKrupa Kansara, Pal Patel, Ritesh K Shukla, Alok Pandya, Rishi Shanker, Ashutosh Kumar, Alok Dhawan Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Over the last decade, there has been growing interest in developing novel nanoparticles (NPs) for biomedical applications. A safe-by-design approach was used in this study to synthesize biocompatible iron oxide NPs. The size of the particles obtained was ~100 nm. Although these NPs were significantly (P<0.05) internalized in MCF-7 (human breast adenocarcinoma cell line) cells, no adverse effect was observed in the cells as assessed by cytotoxicity assays (neutral red uptake and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) and cell cycle analysis. Our data demonstrate the potential of iron oxide NPs as a biocompatible carrier for targeted drug delivery. Keywords: biocompatible iron oxide nanoparticles, human breast adenocarcinoma cells, coprecipitationhttps://www.dovepress.com/synthesis-of-biocompatible-iron-oxide-nanoparticles-as-a-drug-delivery-peer-reviewed-article-IJNBiocompatible Iron Oxide nanoparticleshuman breast adenocarcinoma cellsCo-precipitation |
| spellingShingle | Kansara K Patel P Shukla RK Pandya A Shanker R Kumar A Dhawan A Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle International Journal of Nanomedicine Biocompatible Iron Oxide nanoparticles human breast adenocarcinoma cells Co-precipitation |
| title | Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle |
| title_full | Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle |
| title_fullStr | Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle |
| title_full_unstemmed | Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle |
| title_short | Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle |
| title_sort | synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle |
| topic | Biocompatible Iron Oxide nanoparticles human breast adenocarcinoma cells Co-precipitation |
| url | https://www.dovepress.com/synthesis-of-biocompatible-iron-oxide-nanoparticles-as-a-drug-delivery-peer-reviewed-article-IJN |
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