Fueling recovery: The importance of energy coupling between angiogenesis and osteogenesis during fracture healing
Approximately half of bone fractures that do not heal properly (non-union) can be accounted to insufficient angiogenesis. The processes of angiogenesis and osteogenesis are spatiotemporally regulated in the complex process of fracture healing that requires a substantial amount of energy. It is thoug...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Bone Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235218722400024X |
| _version_ | 1797235568848928768 |
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| author | Fleur van Brakel Yudong Zhao Bram C.J. van der Eerden |
| author_facet | Fleur van Brakel Yudong Zhao Bram C.J. van der Eerden |
| author_sort | Fleur van Brakel |
| collection | DOAJ |
| description | Approximately half of bone fractures that do not heal properly (non-union) can be accounted to insufficient angiogenesis. The processes of angiogenesis and osteogenesis are spatiotemporally regulated in the complex process of fracture healing that requires a substantial amount of energy. It is thought that a metabolic coupling between angiogenesis and osteogenesis is essential for successful healing. However, how this coupling is achieved remains to be largely elucidated. Here, we will discuss the most recent evidence from literature pointing towards a metabolic coupling between angiogenesis and osteogenesis. We will describe the metabolic profiles of the cell types involved during fracture healing as well as secreted products in the bone microenvironment (such as lactate and nitric oxide) as possible key players in this metabolic crosstalk. |
| first_indexed | 2024-04-24T16:50:02Z |
| format | Article |
| id | doaj.art-dc8eba1ec2a649819c5cea66a7395282 |
| institution | Directory Open Access Journal |
| issn | 2352-1872 |
| language | English |
| last_indexed | 2024-04-24T16:50:02Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj.art-dc8eba1ec2a649819c5cea66a73952822024-03-29T05:50:27ZengElsevierBone Reports2352-18722024-06-0121101757Fueling recovery: The importance of energy coupling between angiogenesis and osteogenesis during fracture healingFleur van Brakel0Yudong Zhao1Bram C.J. van der Eerden2Calcium and Bone Metabolism Laboratory, Department of Internal Medicine, Erasmus MC, Erasmus University Medical Center, Rotterdam, the NetherlandsCalcium and Bone Metabolism Laboratory, Department of Internal Medicine, Erasmus MC, Erasmus University Medical Center, Rotterdam, the NetherlandsCorresponding author at: Erasmus MC, University Medical Center Rotterdam, Department of Internal Medicine, Room Ee585b, Dr Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.; Calcium and Bone Metabolism Laboratory, Department of Internal Medicine, Erasmus MC, Erasmus University Medical Center, Rotterdam, the NetherlandsApproximately half of bone fractures that do not heal properly (non-union) can be accounted to insufficient angiogenesis. The processes of angiogenesis and osteogenesis are spatiotemporally regulated in the complex process of fracture healing that requires a substantial amount of energy. It is thought that a metabolic coupling between angiogenesis and osteogenesis is essential for successful healing. However, how this coupling is achieved remains to be largely elucidated. Here, we will discuss the most recent evidence from literature pointing towards a metabolic coupling between angiogenesis and osteogenesis. We will describe the metabolic profiles of the cell types involved during fracture healing as well as secreted products in the bone microenvironment (such as lactate and nitric oxide) as possible key players in this metabolic crosstalk.http://www.sciencedirect.com/science/article/pii/S235218722400024XFracture healingBone regenerationAngiogenesisOsteogenesisEnergy metabolismMetabolic coupling |
| spellingShingle | Fleur van Brakel Yudong Zhao Bram C.J. van der Eerden Fueling recovery: The importance of energy coupling between angiogenesis and osteogenesis during fracture healing Bone Reports Fracture healing Bone regeneration Angiogenesis Osteogenesis Energy metabolism Metabolic coupling |
| title | Fueling recovery: The importance of energy coupling between angiogenesis and osteogenesis during fracture healing |
| title_full | Fueling recovery: The importance of energy coupling between angiogenesis and osteogenesis during fracture healing |
| title_fullStr | Fueling recovery: The importance of energy coupling between angiogenesis and osteogenesis during fracture healing |
| title_full_unstemmed | Fueling recovery: The importance of energy coupling between angiogenesis and osteogenesis during fracture healing |
| title_short | Fueling recovery: The importance of energy coupling between angiogenesis and osteogenesis during fracture healing |
| title_sort | fueling recovery the importance of energy coupling between angiogenesis and osteogenesis during fracture healing |
| topic | Fracture healing Bone regeneration Angiogenesis Osteogenesis Energy metabolism Metabolic coupling |
| url | http://www.sciencedirect.com/science/article/pii/S235218722400024X |
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