The association between acute fatty liver disease and nitric oxide during malaria in pregnancy
Abstract Background Liver disease is a common feature of malaria in pregnancy, but its pathogenesis remains unclear. Methods To understand the pathogenesis of liver disease during malaria in pregnancy, comparative proteomic analysis of the liver in a mouse model of malaria in pregnancy was performed...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12936-021-03999-2 |
| _version_ | 1819177653160116224 |
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| author | Mamoru Niikura Toshiyuki Fukutomi Shoichiro Mineo Jiro Mitobe Fumie Kobayashi |
| author_facet | Mamoru Niikura Toshiyuki Fukutomi Shoichiro Mineo Jiro Mitobe Fumie Kobayashi |
| author_sort | Mamoru Niikura |
| collection | DOAJ |
| description | Abstract Background Liver disease is a common feature of malaria in pregnancy, but its pathogenesis remains unclear. Methods To understand the pathogenesis of liver disease during malaria in pregnancy, comparative proteomic analysis of the liver in a mouse model of malaria in pregnancy was performed. Results Decreased levels of mitochondrial and peroxisomal proteins were observed in the livers of pregnant mice infected with the lethal rodent malaria parasite Plasmodium berghei strain NK65. By contrast, increased levels of perilipin-2, amyloid A-1, and interferon (IFN)-γ signalling pathway-related proteins were observed in the livers of infected pregnant mice, suggesting that IFN-γ signalling may contribute to the development of liver disease during malaria in pregnancy. IFN-γ signalling is a potential trigger of inducible nitric oxide synthase (iNOS) expression. Liver disease associated with microvesicular fatty infiltration and elevated liver enzymes in pregnant wild-type mice infected with malaria parasites was improved by iNOS deficiency. Conclusions In this study, a causative role of iNOS in liver disease associated with microvesicular fatty infiltration during malaria in pregnancy was demonstrated. These findings provide important insight for understanding the role of iNOS-mediated metabolic responses and the pathogenesis of high-risk liver diseases in pregnancy, such as acute fatty liver. |
| first_indexed | 2024-12-22T21:30:04Z |
| format | Article |
| id | doaj.art-dc8fb89229184d1bbad70a2f2241716b |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-22T21:30:04Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-dc8fb89229184d1bbad70a2f2241716b2022-12-21T18:11:57ZengBMCMalaria Journal1475-28752021-12-0120111310.1186/s12936-021-03999-2The association between acute fatty liver disease and nitric oxide during malaria in pregnancyMamoru Niikura0Toshiyuki Fukutomi1Shoichiro Mineo2Jiro Mitobe3Fumie Kobayashi4Department of Infectious Diseases, Kyorin University School of MedicineDepartment of Pharmacology and Toxicology, Kyorin University School of MedicineDepartment of Molecular Pathology, Tokyo Medical UniversityDepartment of Infectious Diseases, Kyorin University School of MedicineDepartment of Environmental Science, School of Life and Environmental Science, Azabu UniversityAbstract Background Liver disease is a common feature of malaria in pregnancy, but its pathogenesis remains unclear. Methods To understand the pathogenesis of liver disease during malaria in pregnancy, comparative proteomic analysis of the liver in a mouse model of malaria in pregnancy was performed. Results Decreased levels of mitochondrial and peroxisomal proteins were observed in the livers of pregnant mice infected with the lethal rodent malaria parasite Plasmodium berghei strain NK65. By contrast, increased levels of perilipin-2, amyloid A-1, and interferon (IFN)-γ signalling pathway-related proteins were observed in the livers of infected pregnant mice, suggesting that IFN-γ signalling may contribute to the development of liver disease during malaria in pregnancy. IFN-γ signalling is a potential trigger of inducible nitric oxide synthase (iNOS) expression. Liver disease associated with microvesicular fatty infiltration and elevated liver enzymes in pregnant wild-type mice infected with malaria parasites was improved by iNOS deficiency. Conclusions In this study, a causative role of iNOS in liver disease associated with microvesicular fatty infiltration during malaria in pregnancy was demonstrated. These findings provide important insight for understanding the role of iNOS-mediated metabolic responses and the pathogenesis of high-risk liver diseases in pregnancy, such as acute fatty liver.https://doi.org/10.1186/s12936-021-03999-2Fatty liveriNOSLiver diseaseMalariaPregnancyProteome |
| spellingShingle | Mamoru Niikura Toshiyuki Fukutomi Shoichiro Mineo Jiro Mitobe Fumie Kobayashi The association between acute fatty liver disease and nitric oxide during malaria in pregnancy Malaria Journal Fatty liver iNOS Liver disease Malaria Pregnancy Proteome |
| title | The association between acute fatty liver disease and nitric oxide during malaria in pregnancy |
| title_full | The association between acute fatty liver disease and nitric oxide during malaria in pregnancy |
| title_fullStr | The association between acute fatty liver disease and nitric oxide during malaria in pregnancy |
| title_full_unstemmed | The association between acute fatty liver disease and nitric oxide during malaria in pregnancy |
| title_short | The association between acute fatty liver disease and nitric oxide during malaria in pregnancy |
| title_sort | association between acute fatty liver disease and nitric oxide during malaria in pregnancy |
| topic | Fatty liver iNOS Liver disease Malaria Pregnancy Proteome |
| url | https://doi.org/10.1186/s12936-021-03999-2 |
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