Targeting with nanoparticles for the therapeutic treatment of brain diseases
Brain diseases including neurodegenerative disorders and tumours are among the most serious health problems, degrading the quality of life and causing massive economic cost. Nanoparticles that load and deliver drugs and genes have been intensively studied for the treatment of brain diseases, and hav...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-03-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/2041731419897460 |
| _version_ | 1828847497230942208 |
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| author | Guang-Zhen Jin Atanu Chakraborty Jung-Hwan Lee Jonathan C Knowles Hae-Won Kim |
| author_facet | Guang-Zhen Jin Atanu Chakraborty Jung-Hwan Lee Jonathan C Knowles Hae-Won Kim |
| author_sort | Guang-Zhen Jin |
| collection | DOAJ |
| description | Brain diseases including neurodegenerative disorders and tumours are among the most serious health problems, degrading the quality of life and causing massive economic cost. Nanoparticles that load and deliver drugs and genes have been intensively studied for the treatment of brain diseases, and have demonstrated some biological effects in various animal models. Among other efforts taken in the nanoparticle development, targeting of blood brain barrier, specific cell type or local intra-/extra-cellular space is an important strategy to enhance the therapeutic efficacy of the nanoparticle delivery systems. This review underlies the targeting issue in the nanoparticle development for the treatment of brain diseases, taking key exemplar studies carried out in various in vivo models. |
| first_indexed | 2024-12-12T22:11:19Z |
| format | Article |
| id | doaj.art-dc9080902eed4379876d6143909adf24 |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-12-12T22:11:19Z |
| publishDate | 2020-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-dc9080902eed4379876d6143909adf242022-12-22T00:10:15ZengSAGE PublishingJournal of Tissue Engineering2041-73142020-03-011110.1177/2041731419897460Targeting with nanoparticles for the therapeutic treatment of brain diseasesGuang-Zhen Jin0Atanu Chakraborty1Jung-Hwan Lee2Jonathan C Knowles3Hae-Won Kim4Department of Nanobiomedical Science and BK21 PLUS Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of KoreaInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Republic of KoreaUCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan, Republic of KoreaDivision of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, London, UKUCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan, Republic of KoreaBrain diseases including neurodegenerative disorders and tumours are among the most serious health problems, degrading the quality of life and causing massive economic cost. Nanoparticles that load and deliver drugs and genes have been intensively studied for the treatment of brain diseases, and have demonstrated some biological effects in various animal models. Among other efforts taken in the nanoparticle development, targeting of blood brain barrier, specific cell type or local intra-/extra-cellular space is an important strategy to enhance the therapeutic efficacy of the nanoparticle delivery systems. This review underlies the targeting issue in the nanoparticle development for the treatment of brain diseases, taking key exemplar studies carried out in various in vivo models.https://doi.org/10.1177/2041731419897460 |
| spellingShingle | Guang-Zhen Jin Atanu Chakraborty Jung-Hwan Lee Jonathan C Knowles Hae-Won Kim Targeting with nanoparticles for the therapeutic treatment of brain diseases Journal of Tissue Engineering |
| title | Targeting with nanoparticles for the therapeutic treatment of brain diseases |
| title_full | Targeting with nanoparticles for the therapeutic treatment of brain diseases |
| title_fullStr | Targeting with nanoparticles for the therapeutic treatment of brain diseases |
| title_full_unstemmed | Targeting with nanoparticles for the therapeutic treatment of brain diseases |
| title_short | Targeting with nanoparticles for the therapeutic treatment of brain diseases |
| title_sort | targeting with nanoparticles for the therapeutic treatment of brain diseases |
| url | https://doi.org/10.1177/2041731419897460 |
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