Silk scaffolding drives self-assembly of functional and mature human brain organoids

Silk scaffolding drives self-assembly of functional and mature human brain organoids

Human pluripotent stem cells (hPSCs) are intrinsically able to self-organize into cerebral organoids that mimic features of developing human brain tissue. These three-dimensional structures provide a unique opportunity to generate cytoarchitecture and cell-cell interactions reminiscent of human brai...

Full description

Bibliographic Details
Main Authors:	Edoardo Sozzi, Janko Kajtez, Andreas Bruzelius, Milan Finn Wesseler, Fredrik Nilsson, Marcella Birtele, Niels B. Larsen, Daniella Rylander Ottosson, Petter Storm, Malin Parmar, Alessandro Fiorenzano
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	human pluripotent stem cells cerebral organoid silk scaffolding tissue engineering oxygen sensing
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2022.1023279/full

Similar Items

Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation
by: Fredrik Nilsson, et al.
Published: (2021-01-01)

Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing
by: Alessandro Fiorenzano, et al.
Published: (2021-06-01)

Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor
by: Congyi Shen, et al.
Published: (2024-05-01)

Recent advances and challenges in organoid-on-a-chip technology
by: Intan Rosalina Suhito, et al.
Published: (2022-04-01)

Recipe for pituitary organoids
by: Mayuko Kano, et al.
Published: (2023-01-01)

Kidney Organoids and Tubuloids
by: Fjodor A. Yousef Yengej, et al.
Published: (2020-05-01)

Brain organoids: Establishment and application
by: Hao Chen, et al.
Published: (2022-11-01)

Bioengineering Human Pluripotent Stem Cell-Derived Retinal Organoids and Optic Vesicle-Containing Brain Organoids for Ocular Diseases
by: Peggy Arthur, et al.
Published: (2022-10-01)

A decade of liver organoids: Advances in disease modeling
by: Yue Liu, et al.
Published: (2023-07-01)

From cells to organs: progress and potential in cartilaginous organoids research
by: Xiao-he Wang, et al.
Published: (2023-12-01)

Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration
by: Veronika Fedorova, et al.
Published: (2023-04-01)

In vitro generation of human pluripotent stem cell derived lung organoids
by: Briana R Dye, et al.
Published: (2015-03-01)

Modeling Autism Spectrum Disorders with Induced Pluripotent Stem Cell-Derived Brain Organoids
by: John Lenon de Souza Santos, et al.
Published: (2023-01-01)

Human Pluripotent Stem Cell-Derived Alveolar Organoid with Macrophages
by: Ha-Rim Seo, et al.
Published: (2022-08-01)

Organoid models of the pituitary gland in health and disease
by: Emma Laporte, et al.
Published: (2023-08-01)

Assessing kidney development and disease using kidney organoids and CRISPR engineering
by: Wajima Safi, et al.
Published: (2022-09-01)

Human cardiac organoids: A recent revolution in disease modeling and regenerative medicine
by: Neda Roshanravan, et al.
Published: (2023-06-01)

Modelling Toxoplasma gondii infection in human cerebral organoids
by: Hyang-Hee Seo, et al.
Published: (2020-01-01)

Genome engineering of stem cell organoids for disease modeling
by: Yingmin Sun, et al.
Published: (2017-01-01)

Methods to extract and analyze fluid from human pluripotent stem cell-derived choroid plexus organoids
by: Leon H. Chew, et al.
Published: (2024-01-01)

Development of otic organoids and their current status
by: Hantai Kim, et al.
Published: (2023-04-01)

Embedded 3D Printing in Self‐Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs
by: Janko Kajtez, et al.
Published: (2022-09-01)

Heart Organoids and Engineered Heart Tissues: Novel Tools for Modeling Human Cardiac Biology and Disease
by: Yonatan R. Lewis-Israeli, et al.
Published: (2021-08-01)

Cerebral organoids in primary progressive multiple sclerosis reveal stem cell and oligodendrocyte differentiation defect
by: Nicolas Daviaud, et al.
Published: (2023-03-01)

Standard operating protocol of hepatic organoid differentiation from human induced pluripotent stem cells
by: Min Jung Kim, et al.
Published: (2022-05-01)

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice
by: Yuyong Tao, et al.
Published: (2019-08-01)

Silk : Processing, Properties and Applications /
by: Babu, K. Murugesh, author 648736, et al.
Published: (2019)

Silk : Materials, Processes, and Applications /
by: Reddy, Narendra, author 650666, et al.
Published: (2020)

Asteroid impact: the potential of astrocytes to modulate human neural networks within organoids
by: S. S. Lavekar, et al.
Published: (2023-11-01)

A beginner’s guide on the use of brain organoids for neuroscientists: a systematic review
by: Lance A. Mulder, et al.
Published: (2023-04-01)

A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids
by: Briana R Dye, et al.
Published: (2016-10-01)

Production of silk sericin/silk fibroin blend nanofibers
by: Zhang Xianhua, et al.
Published: (2011-01-01)

Dynamic Changes and Characterization of the Metal Ions in the Silk Glands and Silk Fibers of Silkworm
by: Qingsong Liu, et al.
Published: (2023-03-01)

Comprehensive characterization of fetal and mature retinal cell identity to assess the fidelity of retinal organoids
by: Hani Jieun Kim, et al.
Published: (2023-01-01)

Alveolar organoids: development of an assay to facilitate pulmonary toxicity assessments
by: Jooyeon Lee, et al.
Published: (2022-11-01)

Protocol for optical clearing and imaging of fluorescently labeled ex vivo rat brain slices
by: Jessica Giacomoni, et al.
Published: (2023-03-01)

Organoid factory: The recent role of the human induced pluripotent stem cells (hiPSCs) in precision medicine
by: Giuseppe Novelli, et al.
Published: (2023-01-01)

Moroccan silk designs in full color /
by: Vogel, Lucien
Published: (1996)

Patient-Derived Induced Pluripotent Stem Cells (iPSCs) and Cerebral Organoids for Drug Screening and Development in Autism Spectrum Disorder: Opportunities and Challenges
by: Chiara Villa, et al.
Published: (2021-02-01)

The Use of Pluripotent Stem Cell-Derived Organoids to Study Extracellular Matrix Development during Neural Degeneration
by: Yuanwei Yan, et al.
Published: (2019-03-01)