Vascularization of intravitreal injection of Conbercept in the treatment of retinopathy of prematurity
AIM: To evaluate retinal vascularization caused by the intravitreal injection of Conbercept in the treatment of a series of retinopathy of prematurity(ROP)cases in Type Ⅰ(threshold and pre-threshold period)and aggressive ROP(A-ROP).METHODS: The data of 34 ROP cases(67 eyes)treated by intravitreal in...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-03-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2023/3/202303003.pdf |
| _version_ | 1811160898428993536 |
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| author | Zheng Fu Wei-Wei Xiong Xue Yin Zhi-Bin Hong Xiu-Ting Li Xi-Xiang Wei Wei-Fang Fang Ya-Juan Chen Jing-Wei Lin Yan-Hui Zhu Yi-Hua Zhu Hui Yang |
| author_facet | Zheng Fu Wei-Wei Xiong Xue Yin Zhi-Bin Hong Xiu-Ting Li Xi-Xiang Wei Wei-Fang Fang Ya-Juan Chen Jing-Wei Lin Yan-Hui Zhu Yi-Hua Zhu Hui Yang |
| author_sort | Zheng Fu |
| collection | DOAJ |
| description | AIM: To evaluate retinal vascularization caused by the intravitreal injection of Conbercept in the treatment of a series of retinopathy of prematurity(ROP)cases in Type Ⅰ(threshold and pre-threshold period)and aggressive ROP(A-ROP).METHODS: The data of 34 ROP cases(67 eyes)treated by intravitreal injection of Conbercept(IVC)in the ophthalmology department of the Xiamen Children's Hospital from July 2017 to March 2020 were retrospectively analyzed. Reactivation, which refers to recurrence of acute phase features, occurred at any stage of the disease in the presence or absence of other diseases. RESULT: The average gestational age of the 34 children was 28.82±2.32wk. The average birth weight was 1155.18±398.22g. The lesion zone of 19 cases(37 eyes)was Zone Ⅰ. In 10 cases(20 eyes), the lesion was in Zone Ⅱ, and in 5 cases(10 eyes), the lesion was in the posterior Zone Ⅱ. The total effective rate of disease control in ROP children treated with once IVC was 73.1%(49/67), and the vascularization of Zone Ⅱ was completed. The patients showed variable changes in the vascularization in Zone Ⅲ. For the patients who received one treatment and did not reactivate, the average rate of Type Ⅰ vascularization of ROP was 9.11±2.49wk, and the A-ROP was 13.40±4.04wk. The rate of A-ROP vascularization in Zone Ⅱ was significantly longer compared to Type Ⅰ.CONCLUSION: IVC effectively completes vascularization in Zone Ⅱ. |
| first_indexed | 2024-04-10T06:06:42Z |
| format | Article |
| id | doaj.art-dc9401b8e76443c693f939c890f36de8 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-10T06:06:42Z |
| publishDate | 2023-03-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-dc9401b8e76443c693f939c890f36de82023-03-03T03:10:42ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-03-0123336336810.3980/j.issn.1672-5123.2023.3.03202303003Vascularization of intravitreal injection of Conbercept in the treatment of retinopathy of prematurityZheng Fu0Wei-Wei Xiong1Xue Yin2Zhi-Bin Hong3Xiu-Ting Li4Xi-Xiang Wei5Wei-Fang Fang6Ya-Juan Chen7Jing-Wei Lin8Yan-Hui Zhu9Yi-Hua Zhu10Hui Yang11Department of Ophthalmology, Children's Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, ChinaDepartment of Ophthalmology, Children's Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, ChinaDepartment of Ophthalmology, Children's Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, ChinaDepartment of Ophthalmology, Children's Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, ChinaDepartment of Ophthalmology, Children's Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, ChinaDepartment of Ophthalmology, Children's Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, ChinaDepartment of Ophthalmology, Children's Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, ChinaDepartment of Ophthalmology, Children's Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, ChinaDepartment of Ophthalmology, Children's Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, ChinaDepartment of Ophthalmology, Children's Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, ChinaDepartment of Ophthalmology, Children's Hospital of Fudan University at Xiamen, Xiamen 361004, Fujian Province, ChinaAIM: To evaluate retinal vascularization caused by the intravitreal injection of Conbercept in the treatment of a series of retinopathy of prematurity(ROP)cases in Type Ⅰ(threshold and pre-threshold period)and aggressive ROP(A-ROP).METHODS: The data of 34 ROP cases(67 eyes)treated by intravitreal injection of Conbercept(IVC)in the ophthalmology department of the Xiamen Children's Hospital from July 2017 to March 2020 were retrospectively analyzed. Reactivation, which refers to recurrence of acute phase features, occurred at any stage of the disease in the presence or absence of other diseases. RESULT: The average gestational age of the 34 children was 28.82±2.32wk. The average birth weight was 1155.18±398.22g. The lesion zone of 19 cases(37 eyes)was Zone Ⅰ. In 10 cases(20 eyes), the lesion was in Zone Ⅱ, and in 5 cases(10 eyes), the lesion was in the posterior Zone Ⅱ. The total effective rate of disease control in ROP children treated with once IVC was 73.1%(49/67), and the vascularization of Zone Ⅱ was completed. The patients showed variable changes in the vascularization in Zone Ⅲ. For the patients who received one treatment and did not reactivate, the average rate of Type Ⅰ vascularization of ROP was 9.11±2.49wk, and the A-ROP was 13.40±4.04wk. The rate of A-ROP vascularization in Zone Ⅱ was significantly longer compared to Type Ⅰ.CONCLUSION: IVC effectively completes vascularization in Zone Ⅱ.http://ies.ijo.cn/cn_publish/2023/3/202303003.pdfconberceptretinopathy of prematurityvascularization |
| spellingShingle | Zheng Fu Wei-Wei Xiong Xue Yin Zhi-Bin Hong Xiu-Ting Li Xi-Xiang Wei Wei-Fang Fang Ya-Juan Chen Jing-Wei Lin Yan-Hui Zhu Yi-Hua Zhu Hui Yang Vascularization of intravitreal injection of Conbercept in the treatment of retinopathy of prematurity Guoji Yanke Zazhi conbercept retinopathy of prematurity vascularization |
| title | Vascularization of intravitreal injection of Conbercept in the treatment of retinopathy of prematurity |
| title_full | Vascularization of intravitreal injection of Conbercept in the treatment of retinopathy of prematurity |
| title_fullStr | Vascularization of intravitreal injection of Conbercept in the treatment of retinopathy of prematurity |
| title_full_unstemmed | Vascularization of intravitreal injection of Conbercept in the treatment of retinopathy of prematurity |
| title_short | Vascularization of intravitreal injection of Conbercept in the treatment of retinopathy of prematurity |
| title_sort | vascularization of intravitreal injection of conbercept in the treatment of retinopathy of prematurity |
| topic | conbercept retinopathy of prematurity vascularization |
| url | http://ies.ijo.cn/cn_publish/2023/3/202303003.pdf |
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