The clinical spectrum of tularemia—Two cases
We report two cases of tularemia with different clinical manifestations, both suspected of tick-borne transmission and with near-complete remission of all symptoms within 3 months after antimicrobial treatment. The first patient presented with a classical ulceroglandular manifestation; general malai...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250920301980 |
| _version_ | 1818356972766887936 |
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| author | Mathilde Ørbæk Anne-Mette Lebech Marie Helleberg |
| author_facet | Mathilde Ørbæk Anne-Mette Lebech Marie Helleberg |
| author_sort | Mathilde Ørbæk |
| collection | DOAJ |
| description | We report two cases of tularemia with different clinical manifestations, both suspected of tick-borne transmission and with near-complete remission of all symptoms within 3 months after antimicrobial treatment. The first patient presented with a classical ulceroglandular manifestation; general malaise, an ulcer and lymphadenopathy, occurring two weeks after a tick bite. Diagnosis was established by polymerase chain reaction of a skin biopsy from the ulcer. The second patient presented with a rare systemic manifestation including bacteremia and myocarditis resulting in severe clinical heart failure, pulmonary edema and secondary kidney failure. Previous tick bites were elucidated after the bacteremia was discovered. The cases underscore the heterogeneity of manifestations, the diagnostic approach and the importance of thorough medical history including recent exposures especially in cases with infection of unknown origin. |
| first_indexed | 2024-12-13T20:05:42Z |
| format | Article |
| id | doaj.art-dc94447931a846fdb0160826fccd97db |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-12-13T20:05:42Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-dc94447931a846fdb0160826fccd97db2022-12-21T23:33:02ZengElsevierIDCases2214-25092020-01-0121e00890The clinical spectrum of tularemia—Two casesMathilde Ørbæk0Anne-Mette Lebech1Marie Helleberg2Department of Infectious Diseases, The National University Hospital, Rigshospitalet, Denmark; Corresponding author.Department of Infectious Diseases, The National University Hospital, Rigshospitalet, Denmark; Institute of Clinical Medicine, University of Copenhagen, DenmarkDepartment of Infectious Diseases, The National University Hospital, Rigshospitalet, DenmarkWe report two cases of tularemia with different clinical manifestations, both suspected of tick-borne transmission and with near-complete remission of all symptoms within 3 months after antimicrobial treatment. The first patient presented with a classical ulceroglandular manifestation; general malaise, an ulcer and lymphadenopathy, occurring two weeks after a tick bite. Diagnosis was established by polymerase chain reaction of a skin biopsy from the ulcer. The second patient presented with a rare systemic manifestation including bacteremia and myocarditis resulting in severe clinical heart failure, pulmonary edema and secondary kidney failure. Previous tick bites were elucidated after the bacteremia was discovered. The cases underscore the heterogeneity of manifestations, the diagnostic approach and the importance of thorough medical history including recent exposures especially in cases with infection of unknown origin.http://www.sciencedirect.com/science/article/pii/S2214250920301980Francisella tularensisTick-borne infectionsClinical manifestationsTreatment |
| spellingShingle | Mathilde Ørbæk Anne-Mette Lebech Marie Helleberg The clinical spectrum of tularemia—Two cases IDCases Francisella tularensis Tick-borne infections Clinical manifestations Treatment |
| title | The clinical spectrum of tularemia—Two cases |
| title_full | The clinical spectrum of tularemia—Two cases |
| title_fullStr | The clinical spectrum of tularemia—Two cases |
| title_full_unstemmed | The clinical spectrum of tularemia—Two cases |
| title_short | The clinical spectrum of tularemia—Two cases |
| title_sort | clinical spectrum of tularemia two cases |
| topic | Francisella tularensis Tick-borne infections Clinical manifestations Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2214250920301980 |
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