Potential Role of Neutrophil Extracellular Traps in Cardio-Oncology
Cardiovascular toxicity has emerged as the leading cause of death in patients undergoing cancer treatment. Thus, cardio-oncology (CO) care must also focus on the prevention and management of related cardiovascular (CV) complications caused by cancer therapy. Neutrophil extracellular traps (NETs)—ent...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/7/3573 |
| _version_ | 1797439174159106048 |
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| author | Kai-Hung Cheng Gregory P. Contreras Ting-Yu Yeh |
| author_facet | Kai-Hung Cheng Gregory P. Contreras Ting-Yu Yeh |
| author_sort | Kai-Hung Cheng |
| collection | DOAJ |
| description | Cardiovascular toxicity has emerged as the leading cause of death in patients undergoing cancer treatment. Thus, cardio-oncology (CO) care must also focus on the prevention and management of related cardiovascular (CV) complications caused by cancer therapy. Neutrophil extracellular traps (NETs)—entities with released DNA, proteases, proinflammatory and prooxidative substances from blasted neutrophils—play an important role in cancer proliferation, propagation metastasis, and incident CV events (acute coronary syndrome, thromboembolic events, and heart failure). Although NETs have been shown to be involved in cancer progression and incident CV events, little is known about their relationship with cardio-oncology, especially on cancer treatment-related cardiovascular toxicity (CTRCT). This review aims to explore the evidence of the impact of NETs on cancer, CV events, and CTRCT, and the possible solutions based on the mechanism of NETs activation and NETs released toxic substances. |
| first_indexed | 2024-03-09T11:47:55Z |
| format | Article |
| id | doaj.art-dc97247f5e794ac393d85c568668bdef |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:47:55Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dc97247f5e794ac393d85c568668bdef2023-11-30T23:18:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01237357310.3390/ijms23073573Potential Role of Neutrophil Extracellular Traps in Cardio-OncologyKai-Hung Cheng0Gregory P. Contreras1Ting-Yu Yeh2Division of Cardiology, Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung 82445, TaiwanAuxergen Inc., Columbus Center, 701 East Pratt Street, Baltimore, MD 21202, USAAuxergen Inc., Columbus Center, 701 East Pratt Street, Baltimore, MD 21202, USACardiovascular toxicity has emerged as the leading cause of death in patients undergoing cancer treatment. Thus, cardio-oncology (CO) care must also focus on the prevention and management of related cardiovascular (CV) complications caused by cancer therapy. Neutrophil extracellular traps (NETs)—entities with released DNA, proteases, proinflammatory and prooxidative substances from blasted neutrophils—play an important role in cancer proliferation, propagation metastasis, and incident CV events (acute coronary syndrome, thromboembolic events, and heart failure). Although NETs have been shown to be involved in cancer progression and incident CV events, little is known about their relationship with cardio-oncology, especially on cancer treatment-related cardiovascular toxicity (CTRCT). This review aims to explore the evidence of the impact of NETs on cancer, CV events, and CTRCT, and the possible solutions based on the mechanism of NETs activation and NETs released toxic substances.https://www.mdpi.com/1422-0067/23/7/3573neutrophil extracellular traps (NETs)cardio-oncology (CO)cancer therapeutics-related cardiovascular dysfunction (CTRCD)cancer treatment-related cardiovascular toxicity (CTRCT) |
| spellingShingle | Kai-Hung Cheng Gregory P. Contreras Ting-Yu Yeh Potential Role of Neutrophil Extracellular Traps in Cardio-Oncology International Journal of Molecular Sciences neutrophil extracellular traps (NETs) cardio-oncology (CO) cancer therapeutics-related cardiovascular dysfunction (CTRCD) cancer treatment-related cardiovascular toxicity (CTRCT) |
| title | Potential Role of Neutrophil Extracellular Traps in Cardio-Oncology |
| title_full | Potential Role of Neutrophil Extracellular Traps in Cardio-Oncology |
| title_fullStr | Potential Role of Neutrophil Extracellular Traps in Cardio-Oncology |
| title_full_unstemmed | Potential Role of Neutrophil Extracellular Traps in Cardio-Oncology |
| title_short | Potential Role of Neutrophil Extracellular Traps in Cardio-Oncology |
| title_sort | potential role of neutrophil extracellular traps in cardio oncology |
| topic | neutrophil extracellular traps (NETs) cardio-oncology (CO) cancer therapeutics-related cardiovascular dysfunction (CTRCD) cancer treatment-related cardiovascular toxicity (CTRCT) |
| url | https://www.mdpi.com/1422-0067/23/7/3573 |
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